{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:36:05Z","timestamp":1790706965330,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Women with polycystic ovary syndrome (PCOS<\/jats:styled-content>) mostly have profound insulin resistance (IR<\/jats:styled-content>) and \u03b2\u2010cell dysfunction. Although thioredoxin\u2010interacting protein (TXNIP<\/jats:styled-content>) is a major regulator in IR<\/jats:styled-content> and insulin secretion, no data on the plasma TXNIP<\/jats:styled-content> level in patients with PCOS<\/jats:styled-content> are available. This study aimed to determine the plasma TXNIP<\/jats:styled-content> level and discuss the relationship between TXNIP<\/jats:styled-content> and \u03b2\u2010cell dysfunction\/IR<\/jats:styled-content> in patients with PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Patients<\/jats:title>Eighty\u2010three women with PCOS<\/jats:styled-content> and 52 controls.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Insulin sensitivity was expressed by M<\/jats:italic> value obtained from euglycaemic\u2013hyperinsulinaemic clamp. Homoeostatic model assessment for \u03b2\u2010cell function (HOMA<\/jats:styled-content>\u2010\u03b2), \u25b3Ins30<\/jats:sub>\/\u25b3Glu30<\/jats:sub> and AUC<\/jats:styled-content>ins\/glu<\/jats:sub> were considered as the indices of fasting state, early\u2010phase and total insulin secretion during oral glucose tolerance test, respectively. To evaluate \u03b2\u2010cell function adjusted for insulin sensitivity, disposition index (DI<\/jats:styled-content>) was used: basal DI<\/jats:styled-content> (DI<\/jats:styled-content>0<\/jats:sub>), early\u2010phase DI<\/jats:styled-content> (DI<\/jats:styled-content>30<\/jats:sub>) and total DI<\/jats:styled-content> (DI<\/jats:styled-content>120<\/jats:sub>). Plasma TXNIP<\/jats:styled-content> levels were measured by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec>Design<\/jats:title>Case\u2010control study.<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with PCOS<\/jats:styled-content> had higher serum TXNIP<\/jats:styled-content>, whereas lower M<\/jats:italic> value, DI<\/jats:styled-content>0<\/jats:sub>, DI<\/jats:styled-content>30<\/jats:sub> and DI<\/jats:styled-content>120<\/jats:sub> than controls (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b705); their TXNIP<\/jats:styled-content> correlated positively with weight,<\/jats:bold> waist\u2010to\u2010hip ratio (WHR<\/jats:styled-content>), body mass index (BMI<\/jats:styled-content>), Ins0<\/jats:sub>, Ins120<\/jats:sub> and HOMA<\/jats:styled-content>\u2010\u03b2 and correlated negatively with M<\/jats:italic> value and DI<\/jats:styled-content>120<\/jats:sub> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b705). Multiple stepwise regression analysis indicated that TXNIP<\/jats:styled-content> remained associated with M<\/jats:italic> value in PCOS<\/jats:styled-content> subjects, after adjusting weight, <\/jats:bold>BMI<\/jats:styled-content>, WHR<\/jats:styled-content>, HOMA<\/jats:styled-content>\u2010\u03b2, Ins0<\/jats:sub>, Ins120<\/jats:sub> and DI<\/jats:styled-content>120<\/jats:sub>. However, no relationship between TXNIP<\/jats:styled-content> and impaired \u03b2\u2010cell function was found.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Serum TXNIP<\/jats:styled-content> is elevated in women with PCOS<\/jats:styled-content> and may be a contributing factor for IR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12192","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T03:37:08Z","timestamp":1362541028000},"page":"538-544","source":"Crossref","is-referenced-by-count":19,"title":["Elevated serum thioredoxin\u2010interacting protein in women with polycystic ovary syndrome is associated with insulin resistance"],"prefix":"10.1111","volume":"80","author":[{"given":"Jinlin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Wu","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuecui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Second Affiliated Hospital of Chongqing Medical University Chongqing 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