{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:48Z","timestamp":1785773508593,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitamin D deficiency (VDD) is common in patients with primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">pHPT<\/jats:styled-content>), and this could affect the clinical expression of the disease. However, few North American or North European studies have addressed this issue, showing vitamin D repletion in only about one\u2010third of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>Vitamin D status was evaluated both in an observational study in a series of 206 consecutive patients with <jats:styled-content style=\"fixed-case\">pHPT<\/jats:styled-content> at diagnosis and in a case\u2010control analysis with 113 age\u2010 and sex\u2010matched healthy blood donors. Vitamin D status was assessed by measuring plasma 25\u2010hydroxy\u2010vitamin D (25OHD) levels and was defined as VDD or severe VDD if 25OHD was &lt;20\u00a0ng\/ml (&lt;50\u00a0n<jats:sc>m<\/jats:sc>) and &lt;10\u00a0ng\/ml (&lt;25\u00a0n<jats:sc>m<\/jats:sc>), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No seasonal variability was observed in 25OHD levels. VDD was observed in 75 of 206 patients (36\u00b74%). The VDD was severe in 24 of 75 patients (11\u00b77%). There was no difference in prevalence of VDD between men and women nor between asymptomatic and \u2018bone and stone\u2019 symptomatic patients. 25OHD levels was negatively correlated with parathyroid hormone, ionized calcium, and bone turnover markers, and positively correlated with phosphate. 25OHD levels were also positively correlated with bone mineral density at all sites measured. In the case\u2010control study, the overall prevalence of VDD and severe VDD was higher in patients with <jats:styled-content style=\"fixed-case\">pHPT<\/jats:styled-content> compared with controls (33\u00b76% <jats:italic>vs<\/jats:italic> 10\u00b76%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001, and 8\u00b78% <jats:italic>vs<\/jats:italic> 1\u00b78%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70337, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that VDD occurs in about one\u2010third of patients with <jats:styled-content style=\"fixed-case\">pHPT<\/jats:styled-content> resident in a Southern European area, a lower figure than previously reported. Moreover, VDD is related to a more severe bone disease, and its prevalence is higher in patients with <jats:styled-content style=\"fixed-case\">pHPT<\/jats:styled-content> than in healthy matched subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12210","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T21:15:49Z","timestamp":1364073349000},"page":"784-790","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin <scp>D<\/scp> status in primary hyperparathyroidism: a <scp>S<\/scp>outhern <scp>E<\/scp>uropean perspective"],"prefix":"10.1111","volume":"79","author":[{"given":"Francesco","family":"Tassone","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetology and Metabolism Santa Croce e Carle Hospital Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gianotti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology and Metabolism Santa 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Giulia","family":"Croce","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology and Metabolism Santa Croce e Carle Hospital Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Magro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology and Metabolism Santa Croce e Carle Hospital Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Cesario","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetology and Metabolism Santa Croce e Carle Hospital Cuneo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Endocrinology Service Galeazzi Institute IRCCS Milan 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