{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:29:06Z","timestamp":1784122146290,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this investigation was to evaluate the effects of hyperprolactinaemia on thyroid function, volume and nodularity in patients with prolactinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>Hyperprolactinaemia has been associated with various autoimmune diseases; however, the data on the correlation between the level of prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>) and thyroid disorders have not been adequately clarified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Forty\u2010eight subjects with new diagnosis of hyperprolactinaemia (group 1) and 39 subjects undergoing treatment for prolactinoma (group 2) were recruited from our outpatient clinic. Fifty\u2010two healthy subjects were included as a control group (group 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>The serum <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>, thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>), thyroxine (free <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>4), thyroidal microsome (anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>) and antithyroglobulin antibodies (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>b) levels were evaluated, and ultrasonographic thyroid volume was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of positive anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>b were significantly higher in group 1 than in groups 2 and 3 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008). Also, the percentage of patients with thyroid heterogeneity were significantly higher in groups 1 and 2 than in group 3 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). The percentage of patients with thyroid nodules were higher in group 1 than in groups 2 and 3 (p<jats:sub>1\u20132<\/jats:sub>\u00a0=\u00a00\u00b703, p<jats:sub>1\u20133<\/jats:sub>\u00a0=\u00a00\u00b705 and p<jats:sub>2\u20133<\/jats:sub>\u00a0=\u00a00\u00b7637). The mean thyroid volume was significantly higher in group 1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), and a positive correlation was found between thyroid volume and the level of <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7616; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001). Prolactin had a significant effect on the total volume according to stepwise multiple linear regression analysis (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> is 0\u00b7268; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with hyperprolactinaemia have significantly increased thyroid volume, thyroid autoimmunity and nodule prevalence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12217","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T07:24:42Z","timestamp":1364801082000},"page":"882-886","source":"Crossref","is-referenced-by-count":31,"title":["Hyperprolactinaemia associated with increased thyroid volume and autoimmune thyroiditis in patients with prolactinoma"],"prefix":"10.1111","volume":"79","author":[{"given":"Muyesser","family":"Sayki Arslan","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Diskapi Y\u0131ld\u0131r\u0131m Beyazid Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Ankara University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya","family":"Topaloglu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Diskapi Y\u0131ld\u0131r\u0131m Beyazid Training and Research Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Tutal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases Diskapi Y\u0131ld\u0131r\u0131m Beyazid Training and Research Hospital Ankara 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