{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:52Z","timestamp":1783486252782,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,27]],"date-time":"2013-05-27T00:00:00Z","timestamp":1369612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine a large population of infants with mild neonatal hyperthyrotrophinaemia (<jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content>) and determine prevalence, clinical characteristics and treatment history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of infants with <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> followed at The <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital for <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ick <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hildren between 2000 and 2011. <jats:styled-content style=\"fixed-case\">MNH<\/jats:styled-content> was defined by an abnormal newborn screen followed by thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) between 5 and 30\u00a0<jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l and normal free T4 (FT4) on confirmatory tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mild neonatal hyperthyrotrophinaemia represented 22\u00b73% of patients (103\/462; 60 boys, 43 girls) within our clinic. Incidence increased from two of 20 in 2000 to 31 of 74 cases in 2010. Seventy eight percent of patients started L\u2010thyroxine (initial dose: 8\u00b73\u00a0\u00b1\u00a02\u00b75 mcg\/kg). The treated group had higher confirmatory TSH levels (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7001) and had undergone thyroid scintigraphy more often (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b70001) compared with the nontreated group. Evidence of overtreatment was detected in 45% of thyroid function tests obtained during treatment. Among the treated infants who had reached 3\u00a0years of age, 45% (<jats:italic>N\u00a0<\/jats:italic>=\u00a014) underwent a trial\u2010off medication. Compared with those not trialled\u2010off therapy, these infants were less likely to have had dose escalations during treatment (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7001). The trial\u2010off treatment was successful in 50% of cases. In the subset of infants with confirmatory TSH\u00a0&gt;10\u00a0<jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l, trial\u2010off therapy was successful in 40%. None of the assessed variables predicted success of trial\u2010off therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mild neonatal hyperthyrotrophinaemia is an increasingly common diagnosis. It is more common in males and is often transient, but predictors of success of trial\u2010off therapy were not identified. Further studies are needed to determine optimum L\u2010thyroxine dosing and to determine whether treatment improves neurocognitive outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12228","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T07:48:48Z","timestamp":1366789728000},"page":"832-837","source":"Crossref","is-referenced-by-count":27,"title":["Mild neonatal hyperthyrotrophinaemia: 10\u2010year experience suggests the condition is increasingly common but often transient"],"prefix":"10.1111","volume":"79","author":[{"given":"Asaf","family":"Oren","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Departments of Pediatrics and Physiology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Brnjac","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid H.","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Departments of Pediatrics and Physiology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Palmert","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology The Hospital for Sick Children Toronto ON Canada"},{"name":"Departments of Pediatrics and Physiology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0915"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i3.95"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1175"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8662"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9062-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(00)90049-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2612"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1975F"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.379"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.00998.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1073"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-141604090-3.50011-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1563"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03634.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.8.1177"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2007.03.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2002.00812.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03568.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0057"},{"key":"e_1_2_8_21_1","unstructured":"Budhwa T.(2008)Niday Perinatal Database for the GTA: Fifth Annual Statistical Report 2007\/2008. 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