{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:29Z","timestamp":1783486229684,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypopituitarism has been widely described in adults after traumatic brain injury (<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>); however, the available data in paediatric populations are scarce. Here, we report the results of a prospective, long\u2010term study in children, adolescents and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study group<\/jats:title><jats:p>Thirty\u2010seven children (age, 2\u00a0months to 19\u00b79\u00a0years) of 51 eligible patients were followed for 1\u00a0year. Clinical and baseline endocrine variables were assessed in all 3 and 12\u00a0months after <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>; children \u2265 6\u00a0years underwent two stimulation tests (glucagon stimulation and megatest).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the group \u22656\u00a0years, 11 of 23 patients (47\u00b78%) had a subnormal <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> peak 3\u00a0months after <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content> that persisted in 8 of 23 patients (34%) after 1\u00a0year. The <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> response showed no correlation with injury severity (<jats:styled-content style=\"fixed-case\">GCS<\/jats:styled-content>, Marshall classification). Growth velocity was normal in all patients, except for one. Body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">SDS<\/jats:styled-content> increased significantly in the group with low <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> response. A suboptimal cortisol was observed in 10 of 23 subjects, which normalized in all but three, 1\u00a0year thereafter. All patients but one showed a pubertal response to Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> testing. No clinical or hormonal abnormalities were detectable in children &lt;6\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results recommend to prospectively follow children after <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>: firstly, because the impairment of pituitary function cannot be predicted, and secondly, to avoid the potential consequences of pituitary dysfunction. Prospective clinical trials are needed before recommending a systematic screening after <jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy either in postpubertal children or in prepubertal children who grow normally.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12237","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T15:43:22Z","timestamp":1367941402000},"page":"853-858","source":"Crossref","is-referenced-by-count":30,"title":["Pituitary dysfunction after traumatic brain injury in children: is there a need for ongoing endocrine assessment?"],"prefix":"10.1111","volume":"79","author":[{"given":"Paula","family":"Casano\u2010Sancho","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Unit Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Endocrinology Hospital Sant Joan de D\u00e9u and CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit Hospital Sant Joan de D\u00e9u University of Barcelona Barcelona Spain"},{"name":"Endocrinology Hospital Sant Joan de D\u00e9u and CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Garc\u00eda\u2010Fructuoso","sequence":"additional","affiliation":[{"name":"Neurosurgery Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julita","family":"Medina","sequence":"additional","affiliation":[{"name":"Rehabilitation Hospital Sant Joan de D\u00e9u Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Febrer","sequence":"additional","affiliation":[{"name":"Rehabilitation Hospital Sant Joan de D\u00e9u Barcelona 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