{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T09:21:22Z","timestamp":1780737682658,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Summary<\/jats:title>Objectives<\/jats:title>Vitamin D<\/jats:styled-content> deficiency (VDD<\/jats:styled-content>) is a global problem. Not all patients with VDD<\/jats:styled-content> have clinical manifestations or secondary hyperparathyroidism. We studied the interaction between serum 25\u2010hydroxy vitamin D<\/jats:styled-content> (25OHD<\/jats:styled-content>), parathormone (PTH<\/jats:styled-content>) and bone mineral density (BMD<\/jats:styled-content>) in Indian adolescents and adults.<\/jats:p><\/jats:sec>Design<\/jats:title>Population survey.<\/jats:p><\/jats:sec>Patients<\/jats:title>A total of 1829 adolescents and 1346 adults aged 50\u00a0years and above were analysed in this study.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Serum biochemistry, 25OHD<\/jats:styled-content>, PTH<\/jats:styled-content> and BMD<\/jats:styled-content> were estimated. Subjects were grouped according to quartiles of serum PTH<\/jats:styled-content>. VDD<\/jats:styled-content> was defined as severe (25OHD<\/jats:styled-content>\u00a0\u2264\u00a05\u00a0ng\/ml), moderate (25OHD<\/jats:styled-content>\u00a0\u2264\u00a010\u00a0ng\/ml) and mild (25OHD<\/jats:styled-content>\u00a0\u2264\u00a020\u00a0ng\/ml) and secondary hyperparathyroidism (SHPT<\/jats:styled-content>) when serum PTH<\/jats:styled-content> levels >65\u00a0pg\/ml.<\/jats:p><\/jats:sec>Results<\/jats:title>Only 30\u201340% of subjects with moderate and severe VDD<\/jats:styled-content>, respectively, had SHPT<\/jats:styled-content>. BMD<\/jats:styled-content> decreased from Quartile 1 to Quartile 4 of PTH<\/jats:styled-content> at all sites among adolescents and adults, with only a marginal decline in serum 25OHD<\/jats:styled-content> levels between these quartiles. Further, within each PTH<\/jats:styled-content> quartile, there was no difference in BMD<\/jats:styled-content> according to categories of VDD<\/jats:styled-content>. Analysing BMD<\/jats:styled-content> in the different PTH<\/jats:styled-content> quartiles, the PTH<\/jats:styled-content> cut\u2010offs beyond which BMD<\/jats:styled-content> showed a significant decline, was 35\u00a0pg\/ml in adolescents and 53\u00a0pg\/ml in adults.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Less than half of the subjects with VDD<\/jats:styled-content> have SHPT<\/jats:styled-content>. BMD<\/jats:styled-content> levels start to decline at PTH<\/jats:styled-content> values currently considered to be normal. These data suggest the need to redefine SHPT in different age groups keeping in mind the relationship between PTH<\/jats:styled-content> and BMD<\/jats:styled-content>. This may also influence the decision to supplement subjects with VDD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12248","type":"journal-article","created":{"date-parts":[[2013,5,18]],"date-time":"2013-05-18T21:18:35Z","timestamp":1368911915000},"page":"41-46","source":"Crossref","is-referenced-by-count":47,"title":["The relationship between serum 25\u2010hydroxy vitamin D<\/scp>, parathormone and bone mineral density in I<\/scp>ndian population"],"prefix":"10.1111","volume":"80","author":[{"given":"M. K.","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Command Hospital (Southern Command) Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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