{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:53:57Z","timestamp":1788836037950,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T00:00:00Z","timestamp":1375056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) is influenced by multiple factors. Recent studies have highlighted a possible relationship between serotonin and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. Patients with neuroendocrine tumours (<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s) frequently have elevated urinary 5\u2010hydroxy\u2010indoleacetic acid (5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content>) levels, a serotonin metabolite. Evaluation of the relationship between 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s may provide insights into the relationship between serotonin and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010year audit of consecutive patients with <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s within two institutions. Relationships between urinary 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content> and dual X\u2010ray absorptiometry (<jats:styled-content style=\"fixed-case\">DEXA<\/jats:styled-content>)\u2010scan\u2010measured <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> were investigated by group comparisons, correlation and regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 65 patients with <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s, 19 did not participate or were excluded. Of 46 subjects evaluated (48\u00b79% males, 63\u00b78 \u00b1\u00a010\u00b75\u00a0years, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 26\u00b76\u00a0\u00b1\u00a04\u00b74\u00a0kg\/m<jats:sup>2<\/jats:sup>) with 32 gastrointestinal, 9 pancreatic, 3 pulmonary and 2 ovarian <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s, 72\u00b73% had the carcinoid syndrome. Median interval from diagnosis was 4\u00b70\u00a0years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 2\u00b70\u20136\u00b70); 41\u00b73% had osteoporosis and 32\u00b76% osteopaenia (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> definition). The group with a higher urinary 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content> had a lower hip <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (total T\u2010score and Z\u2010score), confirmed on individual analysis (Spearman's rank correlation \u22120\u00b741, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004; \u22120\u00b744, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002, respectively); urinary 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content> was not found to be an independent predictor for <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> on multiple linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data of patients with <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s with higher serotonin metabolites having a lower <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> at the hip in group and individual comparisons, warrants further evaluation. Urinary 5\u2010<jats:styled-content style=\"fixed-case\">HIAA<\/jats:styled-content> measurement alone cannot be used to predict future <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. A larger cohort with prospective design including fractures as a clinical outcome will aid these data in determining whether patients with <jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s should be subject to targeted osteoporosis prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12270","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T07:46:43Z","timestamp":1372060003000},"page":"246-252","source":"Crossref","is-referenced-by-count":12,"title":["Are serotonin metabolite levels related to bone mineral density in patients with neuroendocrine tumours?"],"prefix":"10.1111","volume":"80","author":[{"given":"Piya","family":"Sen Gupta","sequence":"first","affiliation":[{"name":"Department of Endocrinology Barts &amp; the London School of Medicine QMUL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Grozinsky\u2010Glasberg","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumor Unit Hadassah\u2010Hebrew University Medical Center Endocrinology and Metabolism Service Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Barts &amp; 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