{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:46:28Z","timestamp":1776177988568,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the efficiency of letrozole, an aromatase inhibitor, in endometrial preparation for cryopreserved\u2013thawed embryo transfer (<jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>) in women with polycystic ovarian syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred and twenty patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> who met the inclusion criteria for the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We assessed <jats:italic>in vitro<\/jats:italic> fertilization outcomes in one hundred and twenty patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (148 cycles) who were prepared for and underwent <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> between June 2011 and December 2012. Patients were prepared for <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content> using artificial hormone cycles induced with oestrogen and progesterone supplementation (<jats:italic>n<\/jats:italic>\u00a0=\u00a076), letrozole stimulation (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) or <jats:styled-content style=\"fixed-case\">hMG<\/jats:styled-content> stimulation (<jats:italic>n<\/jats:italic>\u00a0=\u00a032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in demographic characteristics between the groups, except that the letrozole group had a higher incidence of embryo transfer failure in the past. The letrozole stimulation group had a significantly higher maximal endometrial thickness and significantly higher rates of clinical pregnancy per transfer, ongoing pregnancy per transfer and implantation, compared with the artificial and <jats:styled-content style=\"fixed-case\">hMG<\/jats:styled-content> stimulation groups. Differences in these parameters between the artificial and <jats:styled-content style=\"fixed-case\">hMG<\/jats:styled-content> stimulation groups were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using letrozole stimulation in endometrial preparation for cryopreserved\u2013thawed embryo transfer in patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> may be associated with better outcomes than using hormonal manipulation or <jats:styled-content style=\"fixed-case\">hMG<\/jats:styled-content> stimulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12280","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T11:27:27Z","timestamp":1372678047000},"page":"283-289","source":"Crossref","is-referenced-by-count":43,"title":["Letrozole stimulation in endometrial preparation for cryopreserved\u2013thawed embryo transfer in women with polycystic ovarian syndrome: A pilot study"],"prefix":"10.1111","volume":"80","author":[{"given":"Yan\u2010Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue\u2010Zhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University 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