{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:17:34Z","timestamp":1780085854035,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u2010secreting pituitary adenomas (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u2010omas) are a rare cause of thyrotoxicosis. First\u2010line therapy for these tumours is neurosurgery, although medical therapy with somatostatin analogues (<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>s) is increasingly used for this indication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>We retrospectively reviewed the data of patients with a <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u2010oma (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, 67% males) followed between 1989 and 2011 (median follow\u2010up 7\u00a0years, range 1\u201321) in three academic medical centres in the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etherlands, focusing on the role of <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Patient records were reviewed for clinical, biochemical, imaging, pathological and treatment characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At initial evaluation, biochemical hyperthyroidism with non\u2010suppressed <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> concentrations was detected in 94% of the patients. The majority of patients (72%) had a macroadenoma with extrasellar extension. Fourteen patients underwent surgery, resulting in postoperative euthyroidism in six patients (43%). Recurrence of hyperthyroidism developed in three of them after 5, 24 and 32\u00a0months, respectively. Adjuvant radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) did not induce remission. Three patients received <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> therapy exclusively, resulting in apparent cure in one of them. During long\u2010term follow\u2010up, 72% of all patients required medical therapy (mostly <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> treatment). Euthyroidism was achieved in all but one patient, who refused all treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that patients with <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u2010omas, who often present with large macroadenomas with extrasellar extension, have an excellent response to <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> therapy. Because the results of surgery and radiotherapy are disappointing, primary medical therapy may be considered in virtually all patients, except in case of optic chiasm compression, especially in those harbouring large adenomas with parasellar extension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12290","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T06:32:43Z","timestamp":1373869963000},"page":"395-402","source":"Crossref","is-referenced-by-count":51,"title":["A long\u2010term follow\u2010up study of eighteen patients with thyrotrophin\u2010secreting pituitary adenomas"],"prefix":"10.1111","volume":"80","author":[{"given":"Nad\u00e8ge C.","family":"van Varsseveld","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Section Endocrinology VU University Medical Center Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. L. 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine L.","family":"Drent","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section Endocrinology VU University Medical Center Amsterdam the 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