{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:39:03Z","timestamp":1783694343637,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Type 1 diabetes (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>) is associated with low <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I and altered levels of <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010binding proteins (<jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>s) in plasma. This may be of importance for insulin sensitivity and the risk of developing diabetic complications. We hypothesized that <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I bioactivity is affected by the route of insulin administration and that continuous intraperitoneal insulin infusion (<jats:styled-content style=\"fixed-case\">CIPII<\/jats:styled-content>) has a more pronounced effect than continuous subcutaneous insulin infusion (<jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>We compared 10 patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">CIPII<\/jats:styled-content> with 20 age\u2010 and sex\u2010matched patients on <jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content>. Blood sampling was carried out 7\u20139\u00a0am after an overnight fast. All patients were <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010peptide negative. <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I bioactivity was measured <jats:italic>in vitro<\/jats:italic> using a specific <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I kinase receptor activation (<jats:styled-content style=\"fixed-case\">KIRA<\/jats:styled-content>) assay. <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I was also measured by immunoassay together with <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> IGFBP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When compared with subcutaneous insulin, intraperitoneal insulin resulted in (<jats:styled-content style=\"fixed-case\">CIPII <\/jats:styled-content><jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content>) higher <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I bioactivity (1\u00b783\u00a0\u00b1\u00a00\u00b776 <jats:italic>vs<\/jats:italic> 1\u00b716\u00a0\u00b1\u00a00\u00b724\u00a0\u03bcg\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I (120\u00a0\u00b1\u00a035 <jats:italic>vs<\/jats:italic> 81\u00a0\u00b1\u00a019\u00a0\u03bcg\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (1050\u00a0\u00b1\u00a0136 <jats:italic>vs<\/jats:italic> 879\u00a0\u00b1\u00a0110\u00a0\u03bcg\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702). By contrast, log\u2010transformed <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20101 was reduced (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013), whereas log\u2010transformed <jats:styled-content style=\"fixed-case\">IGFBP<\/jats:styled-content>\u20102 was not different (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b712). There was a positive correlation between <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content> bioactivity and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b769; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and an inverse correlation between <jats:styled-content style=\"fixed-case\">IGF\u2010I<\/jats:styled-content> bioactivity and log<jats:sub>10<\/jats:sub> IGFBP\u20101 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b768, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>in vitro <\/jats:italic><jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u2010I bioactivity was higher in patients treated with <jats:styled-content style=\"fixed-case\">CIPII<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">CSII<\/jats:styled-content> supporting the theory that the route of insulin administration is of importance for the activity of the <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content> system. Intraperitoneal insulin administration may therefore be beneficial by correcting the alterations of the <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content> system in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12296","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T09:02:55Z","timestamp":1374224575000},"page":"58-62","source":"Crossref","is-referenced-by-count":22,"title":["Intraperitoneal insulin delivery to patients with type 1 diabetes results in higher serum <scp>IGF<\/scp>\u2010I bioactivity than continuous subcutaneous insulin infusion"],"prefix":"10.1111","volume":"81","author":[{"given":"Christina A.","family":"Hedman","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medical and Health Sciences Faculty of Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Endocrine Unit County Council of \u00d6sterg\u00f6tland Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Medical Research Laboratories Department of Clinical Medicine Faculty of Health Aarhus University Aarhus Denmark"},{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medical and Health Sciences Faculty of Health Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Endocrine Unit County Council of \u00d6sterg\u00f6tland Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Oskarsson","sequence":"additional","affiliation":[{"name":"Department of Medicine Karolinska University Hospital Huddinge Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans J.","family":"Arnqvist","sequence":"additional","affiliation":[{"name":"Endocrine Unit County Council of \u00d6sterg\u00f6tland Link\u00f6ping Sweden"},{"name":"Department Clinical and Experimental Medicine Faculty of Health Sciences Link\u00f6ping University Link\u00f6ping 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