{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:14:29Z","timestamp":1779912869802,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Iodine deficiency is associated with thyroid dysfunction and adverse pregnancy outcomes. The aim of our study was to investigate the status of iodine saturation in women after spontaneous abortion (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) residing in an iodine\u2010sufficient area and to evaluate their subsequent reproductive health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Nonrandomized prospective follow\u2010up study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We compared urinary iodine concentration (<jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content>) in 171 women 2\u20138\u00a0weeks (median 4) after an early <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> with age\u2010matched controls. Women with known thyroid diseases were excluded. We also analysed a relationship of <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> to serum thyroid\u2010stimulating hormone, free thyroxine, antibodies against thyroid peroxidase and thyroid ultrasound. Afterwards, we followed the women for a median of 38\u00a0months (range 12\u201347). We used a multivariate regression analysis to assess the influence of iodine status and other thyroid biochemical and ultrasound parameters on their subsequent reproductive health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women after <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> were almost twice as likely to suffer from mild iodine deficiency and had lower median <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> as compared to age\u2010matched controls [rate 105\/181 (58\u00b70%) <jats:italic>vs<\/jats:italic> 57\/181 (31\u00b75%), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001, medians <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> 92\u00b700 <jats:italic>vs<\/jats:italic> 117\u00b780\u00a0mcg\/l, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001]. <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> was not influenced by the use of iodine supplements in the previous pregnancy. We did not find any association neither between <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> and thyroid dysfunction and\/or thyroid antibodies, nor between <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> and rates of subsequent successful pregnancies or obstetric complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than half of women after <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>p<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> residing in an iodine\u2010sufficient area are suffering from mild iodine deficiency. However, it does not seem to have a negative impact on their subsequent reproductive health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12298","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T09:32:51Z","timestamp":1377077571000},"page":"452-458","source":"Crossref","is-referenced-by-count":12,"title":["Mild iodine deficiency in women after spontaneous abortions living in an iodine\u2010sufficient area of Czech Republic: prevalence and impact on reproductive health"],"prefix":"10.1111","volume":"80","author":[{"given":"Jan","family":"Jiskra","sequence":"first","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1\u0161","family":"Fait","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"B\u00edlek","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kr\u00e1tk\u00fd","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Bart\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jind\u0159ich","family":"Luk\u00e1\u0161","sequence":"additional","affiliation":[{"name":"Na Homolce Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zde\u0148ka","family":"L\u00edmanov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Teli\u010dka","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Zamrazil","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u0161ka","family":"Potlukov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Medicine 1st Faculty of Medicine General University Hospital Charles University Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.07.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.161950"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Iodine deficiency among Belgian pregnant women not fully corrected by iodine\u2010containing multivitamins: a national cross\u2010sectional survey","volume":"19","author":"Vandevijvere S.","year":"2012","journal-title":"British Journal of Nutrition"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0397"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5020424"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072504322783849"},{"key":"e_1_2_7_8_1","first-page":"262","article-title":"Evaluation of results of iodine 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