{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:52:09Z","timestamp":1791345129515,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Central precocious puberty (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>), treated or untreated, may have implications in adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the reproductive outcome and social adjustment of former <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women between the 3rd and 5th decades of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study of an historical cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Demographic data and gynaecological history of 214 <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women aged 25\u201356\u00a0years [135 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> analogue (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>a)\u2010treated, 18 cyproterone acetate (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>)\u2010treated, 61 untreated] and of 446 controls with normal puberty, matched for age and year of birth, were recorded in a structured interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marital status, education and number of children were similar in <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women and controls. Clinical hyperandrogenism (acne\/hirsutism with oligomenorrhoea) was more frequently reported in <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women than in controls: <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>a\u2010treated 29\u00b76% <jats:italic>vs<\/jats:italic> 17\u00b74% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006), <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010treated 50% <jats:italic>vs<\/jats:italic> 20\u00b74% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704), untreated 34\u00b74% <jats:italic>vs<\/jats:italic> 17\u00b72% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003), with no significant difference between <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> groups. Spontaneous pregnancy was similarly achieved by treated <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> and controls: <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>n<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>a\u2010treated 90\u00b74% <jats:italic>vs<\/jats:italic> 93\u00b74%, <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\u2010treated 86\u00b77% <jats:italic>vs<\/jats:italic> 90\u00b72%. Assisted fertilization rate was higher in untreated <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> than treated <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006) and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703). Untreated <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> was the only parameter associated with clinical hyperandrogenism (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=2\u00b704, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b70\u20134\u00b716, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b707) and fertility problems (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=3\u00b740, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b715\u201310\u00b70, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7047). Course of pregnancy was uneventful in 90\u00b72% of <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women and 90\u00b79% of controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The increased rate of clinical hyperandrogenism among <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women implies that the underlying neuroendocrine dysfunction persists into adult life. Pubertal suppression treatment may have a protective effect as fertility problems were more prevalent only among untreated <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> women. Educational achievements and marital status were unaffected by <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12319","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T16:22:38Z","timestamp":1377793358000},"page":"570-576","source":"Crossref","is-referenced-by-count":66,"title":["Treated and untreated women with idiopathic precocious puberty: long\u2010term follow\u2010up and reproductive outcome between the third and fifth decades"],"prefix":"10.1111","volume":"80","author":[{"given":"Liora","family":"Lazar","sequence":"first","affiliation":[{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes National Center for Childhood Diabetes Schneider Children's Medical Center of Israel Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv 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