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Whether correction of <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> affects serum <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> is unknown. This study evaluated the effects of correction of <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> and GluMet, and determined the associations of <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> with 25\u2010hydroxyvitamin D (25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>) and GluMet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, patients and measurements<\/jats:title><jats:p>This study involved 230 obese children in a cross\u2010sectional part and 72 participants in a prospective part in which children with <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> were treated with vitamin D2 at a dose of 20\u00a0000\u00a0IU daily for 28\u00a0days. All 230 children underwent an oral glucose tolerance test and had their serum total and undercarboxylated <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>s and 25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> measured. Forty of 72 children were reassessed for the GluMet and serum total and undercarboxylated <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>s and 25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> after the vitamin D2 treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the prospective part, correction of <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> by raising mean (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 25\u2010<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content> of 51\u00b75 (12\u00b73) to 141\u00b78 (40\u00b78)\u00a0nmol\/l resulted in an improvement of their GluMet and increase in their whole\u2010body insulin sensitivity index with no changes in their <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> measures. In the cross\u2010sectional part, after adjustments for age, sex and puberty, the total (\u03b2\u00a0=\u00a00\u00b7322) and undercarboxylated <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content>s (\u03b2\u00a0=\u00a00\u00b7315) were positively associated with insulinogenic index, which is an index of insulin secretion (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7034 and 0\u00b7037, respectively) in the group of prediabetic and diabetic children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Correction of <jats:styled-content style=\"fixed-case\">VDI<\/jats:styled-content> increased insulin sensitivity and improved GluMet, but had no effect on serum <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> measures. <jats:styled-content style=\"fixed-case\">OCN<\/jats:styled-content> was associated with increased insulin secretion in children with abnormal GluMet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12337","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:03:19Z","timestamp":1381539799000},"page":"516-523","source":"Crossref","is-referenced-by-count":14,"title":["Effects of correction of vitamin <scp>D<\/scp> insufficiency on serum osteocalcin and glucose metabolism in obese children"],"prefix":"10.1111","volume":"80","author":[{"given":"Preamrudee","family":"Poomthavorn","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palinee","family":"Nantarakchaikul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Mahachoklertwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La\u2010or","family":"Chailurkit","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patcharin","family":"Khlairit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.050013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.02.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.04.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.201"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650091220"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04035.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081234"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0270"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0585"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.12.020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1600-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1837"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2557"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2731"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4455"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.260"},{"key":"e_1_2_8_19_1","unstructured":"WHO(2007)Growth reference data for 5\u201019\u00a0years. 2007 WHO reference. 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