{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:59:08Z","timestamp":1789945148681,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T00:00:00Z","timestamp":1384732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Precocious adrenarche (PA<\/jats:styled-content>) refers to the clinical onset of excess androgen in girls before the age of 8. It is associated with an increased risk of functional ovarian hyperandrogenism after puberty. PA<\/jats:styled-content> may be associated with polycystic ovary syndrome (PCOS<\/jats:styled-content>). We compared pelvic ultrasound (US) findings of girls with PA<\/jats:styled-content> born appropriate for gestational age (AGA<\/jats:styled-content>) to healthy body mass index (BMI<\/jats:styled-content>)\u2010matched peers to determine whether US findings in AGA<\/jats:styled-content>\u2010born PA<\/jats:styled-content> girls are associated with PCOS<\/jats:styled-content> antecedents.<\/jats:p><\/jats:sec>Subjects and methods<\/jats:title>We conducted a cross\u2010sectional study on 56 AGA<\/jats:styled-content>\u2010born girls with PA<\/jats:styled-content> (6\u00b79\u00a0\u00b1\u00a00\u00b76\u00a0years) and 33 BMI<\/jats:styled-content>\u2010matched prepubertal AGA<\/jats:styled-content>\u2010born peers (7\u00b71\u00a0\u00b1\u00a01\u00b70\u00a0years). Hormonal data, homeostasis model assessment of insulin resistance (HOMA<\/jats:styled-content>\u2010IR<\/jats:styled-content>), insulin sensitivity index (ISI<\/jats:styled-content>comp<\/jats:sub>) and pelvic US findings were compared. Associations of pelvic US findings with clinical and metabolic data were investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>Precocious adrenarche girls had greater height and bone age\u2010adjusted uterine length (UL<\/jats:styled-content>; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b701) and UL<\/jats:styled-content> standard deviation score (SDS<\/jats:styled-content>) (P\u00a0<\/jats:italic>=\u00a00\u00b702) than BMI<\/jats:styled-content>\u2010matched peers. Mean ovarian volume (MOV<\/jats:styled-content>), MOV SDS<\/jats:styled-content>, uterine volume, uterine cross\u2010sectional area and ovarian morphology were similar between the groups (P<\/jats:italic>\u00a0>\u00a00\u00b705). MOV<\/jats:styled-content> and MOV SDS<\/jats:styled-content> correlated with ISI<\/jats:styled-content>comp<\/jats:sub> (r<\/jats:italic>\u00a0=\u00a0\u22120\u00b7683, P<\/jats:italic>\u00a0<\u00a00\u00b7001; r<\/jats:italic>\u00a0=\u00a0\u22120\u00b7760, P<\/jats:italic>\u00a0<\u00a00\u00b7001; respectively). Correlations of pelvic US findings with other biochemical data did not reach significance (P<\/jats:italic>\u00a0>\u00a00\u00b705). Multivariate regression analysis revealed that in girls with PA<\/jats:styled-content>, ISI<\/jats:styled-content>comp<\/jats:sub> had the most significant effect on MOV SDS<\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00\u00b7731, \u03b2\u00a0=\u00a0\u22124\u00b7784, P\u00a0<\/jats:italic>=\u00a00\u00b7001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Appropriate for gestational age\u2010born PA<\/jats:styled-content> girls have greater UL<\/jats:styled-content> measurements than AGA<\/jats:styled-content>\u2010born BMI<\/jats:styled-content>\u2010matched peers. In AGA<\/jats:styled-content>\u2010born girls with PA<\/jats:styled-content>, decreasing insulin sensitivity is strongly and independently associated with an increase in MOV. Longitudinal follow\u2010up of our cohort after menarche will allow us to establish how many AGA<\/jats:styled-content>\u2010born girls with PA<\/jats:styled-content> will ultimately develop PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12355","type":"journal-article","created":{"date-parts":[[2013,10,21]],"date-time":"2013-10-21T13:46:57Z","timestamp":1382363217000},"page":"699-705","source":"Crossref","is-referenced-by-count":6,"title":["Pelvic ultrasound findings in prepubertal girls with precocious adrenarche born appropriate for gestational age"],"prefix":"10.1111","volume":"80","author":[{"given":"Ahmet","family":"U\u00e7ar","sequence":"first","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz Bulent","family":"Erol","sequence":"additional","affiliation":[{"name":"Division of Paediatric Radiology Department of Radiology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensar","family":"Yekeler","sequence":"additional","affiliation":[{"name":"Division of Paediatric Radiology Department of Radiology Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Bozlak","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur\u00e7in","family":"Saka","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdevs","family":"Ba\u015e","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e\u00fckran","family":"Poyrazo\u011flu","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcveyde","family":"Bundak","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Kubat Uzum","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"Gul","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics Istanbul Faculty of Medicine Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2412"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.6.671"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04475.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.03.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.061"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.06.015"},{"key":"e_1_2_7_10_1","first-page":"1","volume-title":"Polycystic Ovary Syndrome. 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