{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:01:38Z","timestamp":1792098098530,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81172689"],"award-info":[{"award-number":["81172689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Secreted frizzled\u2010related protein 5 (<jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5) is a novel anti\u2010inflammatory adipokine, which has been shown as a mediator between obesity and its comorbidities. The aim of this study was to evaluate the associations of <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 with metabolic syndrome (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>et<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>) and the effects of lifestyle interventions on circulating <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 levels in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study was conducted among 111 obese children and 49 lean controls, and a lifestyle intervention was performed in a subgroup of 31 obese children for 6\u00a0months. Anthropometric parameters, clinical data and circulating <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 levels were measured at baseline and after lifestyle intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Secreted frizzled\u2010related protein 5 was significantly lower in obese children, especially in those with <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>et<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>, and negatively correlated with body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), waist circumference and homeostasis model assessment of insulin resistance. Independent of other well\u2010known risk factors, <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 was a significant predictor of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>et<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content> in children. In the longitudinal study, lifestyle intervention led to significant weight loss and higher <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 levels. Furthermore, changes in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> significantly correlated with the rising magnitude of <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">SFRP<\/jats:styled-content>5 is regulated by weight status and seems to be correlated with metabolic disorders in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12361","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T15:50:00Z","timestamp":1383839400000},"page":"363-369","source":"Crossref","is-referenced-by-count":40,"title":["<scp>SFRP<\/scp>5 correlates with obesity and metabolic syndrome and increases after weight loss in children"],"prefix":"10.1111","volume":"81","author":[{"given":"Xinrui","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an 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