{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:42:29Z","timestamp":1782553349926,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["OTKA 84196"],"award-info":[{"award-number":["OTKA 84196"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0031"],"award-info":[{"award-number":["T\u00c1MOP-4.2.2.A-11\/1\/KONV-2012-0031"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chemerin is a recently described adipokine expressed primarily in the white adipose tissue. Compared with lean subjects, circulating chemerin levels are significantly elevated in obese individuals and correlate positively with the prevalence of various cardiovascular risk factors including altered lipoprotein levels. To date, the impact of chemerin on lipoprotein subfractions and its role in atherosclerotic processes are still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Fifty nondiabetic obese (<jats:styled-content style=\"fixed-case\">NDO<\/jats:styled-content>) patients and 38 lean controls matched in age and gender were enrolled. Chemerin level was measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Low\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>) and high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) subfractions were detected by nongradient polyacrylamide gel electrophoresis (<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ipoprint).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We detected significantly higher serum chemerin levels in <jats:styled-content style=\"fixed-case\">NDO<\/jats:styled-content> patients compared with healthy controls (590\u00b71\u00a0\u00b1\u00a0190\u00b73\u00a0ng\/ml <jats:italic>vs<\/jats:italic> 405\u00a0\u00b1\u00a0127\u00b71\u00a0ng\/ml, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). A significant positive correlation was found between chemerin and <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> cholesterol levels, while chemerin showed a significant negative correlation with the level of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> cholesterol. Significant positive correlation was detected between chemerin and the ratio of small dense <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>, while chemerin correlated negatively with the mean <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content> size. Also, a significant negative correlation was found between serum chemerin and the ratio of large <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> subfraction, while there were significant positive correlations between chemerin levels and intermediate and small <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> subfraction ratios, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chemerin may be involved in the regulation of lipoprotein metabolism in obese patients who do not show apparent abnormalities of glucose metabolism. Early changes in the distribution of the lipoprotein subfractions may contribute to the progression of atherosclerosis, leading to increased cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12363","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T09:07:11Z","timestamp":1383901631000},"page":"370-377","source":"Crossref","is-referenced-by-count":31,"title":["Strong correlations between circulating chemerin levels and lipoprotein subfractions in nondiabetic obese and nonobese subjects"],"prefix":"10.1111","volume":"81","author":[{"given":"Hajnalka","family":"L\u0151rincz","sequence":"first","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Katk\u00f3","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariann","family":"Harangi","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Somodi","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Ga\u00e1l","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Paragh","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Seres","sequence":"additional","affiliation":[{"name":"Division of Metabolic Diseases Department of Medicine University of Debrecen Medical and Health Science Center Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.5.317"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0175"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504868200"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2010.08.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700793200"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04217.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e3283576a60"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3673"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2374"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32833b7756"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0273rev"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0500"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(95)80012-H"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.03.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.4.1421"},{"key":"e_1_2_8_19_1","first-page":"428","article-title":"The increase of serum chemerin concentration is mainly associated with the increase of BMI in obese, non\u2010diabetic subjects","volume":"36","author":"Sledzinski T.","year":"2013","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3181ec5db2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03664.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0380"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12249"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03353.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.1735"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-009-3342-2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111144"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.04.004"},{"key":"e_1_2_8_29_1","first-page":"285","article-title":"Aortic vascular inflammation in psoriasis is associated with HDL particle size and concentration: a pilot study","volume":"2","author":"Yu Y.","year":"2012","journal-title":"American Journal of Cardiovascular Disease"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R039297"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000146094.59640.13"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:52:43Z","timestamp":1696301563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/cen.12363"],"URL":"https:\/\/doi.org\/10.1111\/cen.12363","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,5]]}}}