{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:21:25Z","timestamp":1774686085354,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Quality of life is impaired in polycystic ovary syndrome (PCOS<\/jats:styled-content>). In this study, we compared the time to first prescription of antidepressants (ADM<\/jats:styled-content>) in PCOS<\/jats:styled-content> vs<\/jats:italic> two control groups.<\/jats:p><\/jats:sec>Design<\/jats:title>Register\u2010based cohort study.<\/jats:p><\/jats:sec>Patients<\/jats:title>One thousand and one hundred and twenty\u2010four premenopausal women with hirsutism and\/or PCOS<\/jats:styled-content>, premenopausal women with hypertension (HT<\/jats:styled-content>, n<\/jats:italic>\u00a0=\u00a0301), and age\u2010 and sex\u2010matched population controls (controls, n<\/jats:italic>\u00a0=\u00a04110).<\/jats:p><\/jats:sec>Measurements<\/jats:title>Prescriptions for ADM<\/jats:styled-content> on secondary care contacts from regional registers.<\/jats:p><\/jats:sec>Results<\/jats:title>The median age at cohort entry in PCOS<\/jats:styled-content>, HT<\/jats:styled-content> and controls was 29, 34 and 29\u00a0years, respectively. Among PCOS<\/jats:styled-content>, HT<\/jats:styled-content> and controls, 227 (20%), 74 (25%) and 633 (15%), respectively, had prescriptions of ADM<\/jats:styled-content>. The median time to first prescription of ADM<\/jats:styled-content> in the PCOS<\/jats:styled-content>, HT<\/jats:styled-content> and control cohorts was 6\u00b78, 6\u00b76 and 7\u00b72\u00a0years, respectively. The adjusted hazard ratio for time to prescription of ADM<\/jats:styled-content> for HT<\/jats:styled-content> vs<\/jats:italic> PCOS<\/jats:styled-content> was 1\u00b736 [95% CI<\/jats:styled-content> (1\u00b702\u20131\u00b782)], P<\/jats:italic>\u00a0=\u00a00\u00b7039, and for controls vs<\/jats:italic> PCOS<\/jats:styled-content>, it was 0\u00b775 [95% CI<\/jats:styled-content> (0\u00b764\u20130\u00b788)], P<\/jats:italic>\u00a0<\u00a00\u00b7001. Within patients with PCOS<\/jats:styled-content>, hyperandrogenism contributed significantly to the model, likelihood ratio test P<\/jats:italic>\u00a0=\u00a00\u00b7009. The adjusted hazard ratio for hyperandrogenism vs<\/jats:italic> no hyperandrogenism was 1\u00b797 (1\u00b712\u20133\u00b745), P<\/jats:italic>\u00a0=\u00a00\u00b7018.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Patients with PCOS<\/jats:styled-content> had moderately but significantly decreased time to first prescription of ADM<\/jats:styled-content> compared with age\u2010matched healthy women, whereas patients with HT<\/jats:styled-content> had the shortest time to prescription. In PCOS<\/jats:styled-content>, prescription of ADM<\/jats:styled-content> was associated with the presence of hyperandrogenism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12365","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T06:27:05Z","timestamp":1384410425000},"page":"884-889","source":"Crossref","is-referenced-by-count":19,"title":["Prescription of antidepressants is increased in D<\/scp>anish patients with polycystic ovary syndrome and is associated with hyperandrogenism. A population\u2010based cohort study"],"prefix":"10.1111","volume":"80","author":[{"given":"M. L.","family":"Altinok","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Odense University Hospital Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Odense University Hospital Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"dePont Christensen","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hallas","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Pharmacology University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Odense University Hospital Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903247873"},{"key":"e_1_2_6_3_1","first-page":"19","article-title":"Revised 2003 consensus on diagnostic criteria and long\u2010term health risks related to polycystic ovary syndrome","volume":"1","author":"Rotterdam ESHRE\/ASRM\u2010Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertility and 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