{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:42:27Z","timestamp":1770136947500,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Traditional methods of bone densitometry may not provide a comprehensive assessment of bone health. We aimed to assess bone micro\u2010architecture and bone marrow adiposity (<jats:styled-content style=\"fixed-case\">BMA<\/jats:styled-content>) by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in adults with osteogenesis imperfecta (<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>) and endocrinopathy including <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficiency and\/or hypogonadism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>High\u2010resolution micro\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> images were acquired at the tibia using 3T <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> to calculate parameters of bone micro\u2010architecture in seven adults with <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> and 10 adults with endocrinopathies. <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> Spectroscopy was performed in participants to calculate vertebral <jats:styled-content style=\"fixed-case\">BMA<\/jats:styled-content>, which was expressed as percentage fat fraction (%<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content>). Lumbar spine <jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content> was performed to assess bone mineral density. The <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> data were compared with a group of 22 healthy adults who were divided into two age\u2010matched control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010operator repeatability was high, with an average CoV of 1% for micro\u2010<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> and 2\u00b75% for <jats:styled-content style=\"fixed-case\">MRS<\/jats:styled-content>. The ratio of apparent bone volume to total volume (app<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content>) in the endocrinopathy and <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> groups was lower than in age\u2010matched control groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008 respectively). A weak association between <jats:styled-content style=\"fixed-case\">DXA BMD<\/jats:styled-content> and app<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TV<\/jats:styled-content> was also observed (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b75, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7045). %<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> was higher in the endocrinopathy group than in the age\u2010matched control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005), but no difference in %<jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> was observed between the <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content> group and their age\u2010matched control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b726).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> provides valuable detailed information on the micro\u2010architecture and adiposity of bones and is capable of showing clear differences in bone parameters in a range of clinical conditions associated with abnormal bone health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12367","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T08:53:13Z","timestamp":1384851193000},"page":"811-817","source":"Crossref","is-referenced-by-count":10,"title":["<scp>MRI<\/scp>\u2010based abnormalities in young adults at risk of adverse bone health due to childhood\u2010onset metabolic &amp; endocrine conditions"],"prefix":"10.1111","volume":"80","author":[{"given":"C.","family":"McComb","sequence":"first","affiliation":[{"name":"Department of Clinical Physics NHS Greater Glasgow &amp; Clyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Harpur","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Yacoubian","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Leddy","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Perry","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Clinical Physics NHS Greater Glasgow &amp; Clyde Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Developmental Endocrinology Research Group School of Medicine University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra053077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2005.01469.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.118265"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050221"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1973-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.08.054"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.1.111"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1258"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2009.12.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22489"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2532"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1520"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050606"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.10.179"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1585-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091015"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12132"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151S061"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3634"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2668-0"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1477"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011513223894"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391402"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61091-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070701"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12367","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:54:02Z","timestamp":1696301642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/cen.12367"],"URL":"https:\/\/doi.org\/10.1111\/cen.12367","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,12]]}}}