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As Brain\u2010derived neurotrophic factor (BDNF<\/jats:styled-content>) decreases hyperglycaemia and hyperphagia, we aimed to investigate the potential role of placental and circulating BDNF<\/jats:styled-content> levels in these pregnancy\u2010related metabolic changes in rats and humans.<\/jats:p><\/jats:sec>Design and methods<\/jats:title>We identified the mRNA<\/jats:styled-content> and protein expression of placental BDNF<\/jats:styled-content> and its receptor TrkB<\/jats:styled-content> using real\u2010time PCR<\/jats:styled-content>, Western blot and immunohistochemical approaches in both rat and humans. Serum BDNF<\/jats:styled-content> was measured by ELISA<\/jats:styled-content>. We also did a longitudinal prospective cohort study in 42 pregnant women to assess BDNF<\/jats:styled-content> levels and correlations with other metabolic parameters.<\/jats:p><\/jats:sec>Results<\/jats:title>We found that BDNF<\/jats:styled-content> and TrkB<\/jats:styled-content> are expressed in both rat and human placenta. In rat, both placental mRNA<\/jats:styled-content> and serum levels are increased throughout pregnancy, whereas their protein levels are significantly decreased at the end of gestation. Serum BDNF<\/jats:styled-content> levels in pregnant women are significantly lower in the first trimester when compared to the second and third trimester (P<\/jats:italic>\u00a0<\u00a00\u00b70148, P<\/jats:italic>\u00a0<\u00a00\u00b70012, respectively). Serum BDNF<\/jats:styled-content> levels were negatively correlated with gestational age at birth and fasting glucose levels.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings suggest that both BDNF<\/jats:styled-content> and its receptor TrkB<\/jats:styled-content> are expressed in rodent and human placenta being regulated during pregnancy. Taken together, these findings support a role of BDNF<\/jats:styled-content> in the regulation of several metabolic functions during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12391","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T00:24:01Z","timestamp":1387585441000},"page":"141-151","source":"Crossref","is-referenced-by-count":46,"title":["Brain\u2010derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species"],"prefix":"10.1111","volume":"81","author":[{"given":"Mar\u00eda F.","family":"Garc\u00e9s","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine Universidad Nacional de Colombia Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine Universidad Nacional de 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Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoila E.","family":"Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Area of Basic Sciences School of Medicine Universidad El Bosque Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrella","family":"Sanchez\u2010Rebordelo","sequence":"additional","affiliation":[{"name":"Department of Physiology (CIMUS) School of Medicine\u2010Instituto de Investigaciones Sanitarias (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Di\u00e9guez","sequence":"additional","affiliation":[{"name":"Department of Physiology (CIMUS) School of Medicine\u2010Instituto de Investigaciones Sanitarias (IDIS) Universidad de Santiago de Compostela Santiago de Compostela Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Santiago de Compostela 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