{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:08:28Z","timestamp":1768921708285,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T00:00:00Z","timestamp":1391126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare insulin resistance (<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) and metabolic characteristics of different phenotypes of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) and healthy controls in a representative sample of reproductive\u2010aged Iranian women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional community\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Of 915 participants, 136 met Rotterdam criteria for <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and were divided in four subgroups: ovulatory dysfunction with polycystic ovaries (Anovu\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>), hyperandrogenism with <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>), hyperandrogenism with ovulatory dysfunction (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\u00a0+\u00a0Anovu) and full Rotterdam (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\u00a0+\u00a0Anovu\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>). Also 423 subjects served as normal controls, and the rest of participants were analysed as isolated <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, Anovu or <jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Anthropometric measures, biochemical parameters and <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> were compared between different groups. <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> was defined using the homeostatic model assessment\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and normal women were 26\u00b75% and 23\u00b79%, respectively (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b703). After age and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> adjustment, there was no difference regarding metabolic characteristics between different <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> phenotypes. Also metabolic characteristics, fasting insulin and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> were comparable in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> subjects with hyperandrogenism and the nonhyperandrogenic phenotype (Anovu\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PCO<\/jats:styled-content>). In regression analysis, only overweight and obesity (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u00a0\u2265\u00a025\u00a0kg\/m<jats:sup>2<\/jats:sup>) had an independent association with <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2\u00b749, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b706\u20135\u00b782, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b703).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a representative sample of an Iranian <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> population, there is no significant difference between different <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> phenotypes or between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women and normal subjects regarding their metabolic characteristics. These findings suggest that overall metabolic screening may not always be required for all women diagnosed with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. Larger\u2010scale population\u2010based studies are needed to further assess these issues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12406","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T05:48:52Z","timestamp":1389851332000},"page":"93-99","source":"Crossref","is-referenced-by-count":30,"title":["Metabolic aspects of different phenotypes of polycystic ovary syndrome: Iranian <scp>PCOS<\/scp> Prevalence Study"],"prefix":"10.1111","volume":"81","author":[{"given":"Farhad","family":"Hosseinpanah","sequence":"first","affiliation":[{"name":"Obesity Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Barzin","sequence":"additional","affiliation":[{"name":"Obesity Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran 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