{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:06:36Z","timestamp":1773799596395,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T00:00:00Z","timestamp":1392422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Agency for Science, Technology and Innovation 09-067180","award":["09-06180"],"award-info":[{"award-number":["09-06180"]}]},{"name":"Danish Council for Strategic Research 2009 (DAN-ED)","award":["2107-05-0006"],"award-info":[{"award-number":["2107-05-0006"]}]},{"name":"EU FP7 (DEER)","award":["212844"],"award-info":[{"award-number":["212844"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in determining adrenal volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the potential usefulness of <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content> methodology, to estimate adrenal size in healthy children and to evaluate determinants of adrenal volume such as age, gender, body size, pubic hair stage and serum levels of adrenal androgens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Two hundred and thirty\u2010five healthy children (116 girls and 119 boys) (age range 10\u00b70\u201314\u00b78\u00a0years) were examined by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. Clinical examinations (anthropometry and pubertal staging) were performed, and five androgen metabolites were measured in blood samples by liquid chromatography\u2010tandem mass spectrometry (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>It was possible to determine adrenal volume in 115\/235 children using <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. The adrenals were not measurable in 51% of children due to breathing and moving artefacts. The median volume of the right adrenal gland was 0\u00b746\u00a0ml in girls and 0\u00b746\u00a0ml in boys. The median volume of the left adrenal gland was 0\u00b734\u00a0ml in girls and 0\u00b740\u00a0ml in boys. Adrenal size was positively associated with body surface area (estimate B\u00a0=\u00a00\u00b734\u00a0ml\/year, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003), age (estimate B\u00a0=\u00a00\u00b705\u00a0ml\/year, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7021) and pubic hair stage (estimate B\u00a0=\u00a00\u00b705\u00a0ml\/stage, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7075). No associations between adrenal size and serum levels of adrenal androgens were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was possible to determine adrenal volume by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in only 50% of healthy children aged 10\u201315\u00a0years. Adrenal volume increased with age and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anner stage of pubic hair. Future studies will unravel whether adrenal <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> is useful when evaluating children with adrenal diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12414","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T11:58:20Z","timestamp":1390564700000},"page":"183-189","source":"Crossref","is-referenced-by-count":12,"title":["Determination of adrenal volume by <scp>MRI<\/scp> in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens"],"prefix":"10.1111","volume":"81","author":[{"given":"Annette","family":"Mouritsen","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Lindhardt","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Wohlfahrt\u2010Veje","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper P.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanette","family":"Tinggaard","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel G.","family":"Mieritz","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Tefre de Renzy\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tue","family":"Soeborg","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fallentin","sequence":"additional","affiliation":[{"name":"Department of Radiology Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina M.","family":"Main","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Rigshospitalet Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1929"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.146.1.6849039"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910030"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000157871"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1969.tb03270.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.1210\/jcem.86.9.7863","article-title":"The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process","volume":"86","author":"Palmert M.R.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1571"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.6.671"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01858.x"},{"key":"e_1_2_7_11_1","first-page":"115","volume-title":"Control of the Onset of Puberty","author":"Grumbach M.M.","year":"1974"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.44.030182.003115"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199105000-00015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.037325"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710223171717"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.01.019"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12193"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841850903352620"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-982518"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2007.02.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0191"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12414","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:50:19Z","timestamp":1696330219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,15]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cen.12414"],"URL":"https:\/\/doi.org\/10.1111\/cen.12414","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,15]]}}}