{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:32:39Z","timestamp":1781620359062,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to determine the predictive factors for central compartment lymph node metastasis (<jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>) in papillary thyroid microcarcinoma (<jats:styled-content style=\"fixed-case\">PTMC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>We undertook a retrospective study of 291 patients treated for <jats:styled-content style=\"fixed-case\">PTMC<\/jats:styled-content>. The following criteria were assessed to predict the presence of central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>: sex, age, tumour multifocality, tumour size, tumour bilaterality, extracapsular spread (<jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content>), lateral neck <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>, coexistence of chronic lymphocytic thyroiditis, <jats:styled-content style=\"fixed-case\">BRAF<jats:sup>V<\/jats:sup><\/jats:styled-content><jats:sup>600E<\/jats:sup> mutation and ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) features. Univariate and multivariate analyses were performed to identify clinicopathological characteristics and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> findings in predicting central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">PTMC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> affected 133 (45\u00b77%) of 291 patients. With use of univariate and multivariate analyses, male gender (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2\u00b7020; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7039), tumour size (&gt;5\u00a0mm) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3\u00b7687; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7015), <jats:styled-content style=\"fixed-case\">ESC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2\u00b7330; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7044), lateral <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 15\u00b7075; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7000) and <jats:styled-content style=\"fixed-case\">BRAF<jats:sup>V<\/jats:sup><\/jats:styled-content><jats:sup>600E<\/jats:sup> mutation (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2\u00b7464; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7000) were independently correlated with central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>. Age, tumour multifocality, tumour bilaterality, coexistence of chronic lymphocytic thyroiditis and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> characteristics were not significantly related to the presence of central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content>. We have also developed a nomogram to predict the probability of central compartment <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> for an individual patient. The sensitivity was 71\u00b79% and specificity was 70\u00b73%, with an under the receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve of 0\u00b7772.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A prophylactic neck dissection of the central compartment should be considered particularly in <jats:styled-content style=\"fixed-case\">PTMC<\/jats:styled-content> patients with male gender, a &gt;5\u00a0mm tumour size, <jats:styled-content style=\"fixed-case\">ECS<\/jats:styled-content> of the tumours, lateral <jats:styled-content style=\"fixed-case\">LNM<\/jats:styled-content> and positive <jats:styled-content style=\"fixed-case\">BRAF<jats:sup>V<\/jats:sup><\/jats:styled-content><jats:sup>600E<\/jats:sup> mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12417","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T17:14:49Z","timestamp":1391188489000},"page":"282-288","source":"Crossref","is-referenced-by-count":83,"title":["Prediction of central compartment lymph node metastasis in papillary thyroid microcarcinoma"],"prefix":"10.1111","volume":"81","author":[{"given":"Yinlong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Shanghai China"},{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengze","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Wenzhou Medical University  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Langping","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.6.650"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.1600"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0113-y"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055273.58908.19"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9453-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.1426"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1129-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9224-y"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2372"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6484"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0044-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.01.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1546"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021702"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318161f9d1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21055"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2096-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-012-1826-3"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0213-2"},{"key":"e_1_2_6_21_1","first-page":"225","article-title":"Microcarcinoma and incidental carcinoma of the thyroid in a clinical series: clinical behaviour and surgical management","volume":"157","author":"Antonaci A.","year":"2006","journal-title":"La Clinica Terapeutica"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(05)70090-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20606"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690201000207"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.2.5443"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21594"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0007"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1717"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2353"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0987"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E-208"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1383-1"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21258"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1469"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0541-1"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3059"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12417","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12417","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T10:50:21Z","timestamp":1696330221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cen.12417"],"URL":"https:\/\/doi.org\/10.1111\/cen.12417","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,3]]}}}