{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:01:31Z","timestamp":1790276491085,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Context<\/jats:title>Localization of phosphatonin\u2010producing mesenchymal tumours in patients with primary tumour\u2010induced osteomalacia (pTIO<\/jats:styled-content>) is challenging. Functional imaging plays an important role in the localization of these tumours.<\/jats:p><\/jats:sec>Objective<\/jats:title>We studied the relative performance of different functional imaging modalities (18<\/jats:sup>F\u2010FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content>, 99<\/jats:sup>Tc\u2010HYNIC<\/jats:styled-content>\u2010TOC SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> and 68<\/jats:sup>Ga\u2010DOTATATE PET<\/jats:styled-content>\/CT<\/jats:styled-content>) in tumour localization in cases of pTIO<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design and Methods<\/jats:title>Retrospective chart evaluation of 16 patients with confirmed TIO<\/jats:styled-content> treated from 2006 to 2013 was conducted in a tertiary care referral centre.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 16, nine patients had pTIO<\/jats:styled-content>. In these nine, the positivity rates of different functional imaging modalities were 50% for 18<\/jats:sup> F\u2010FDG PET<\/jats:styled-content>\/CT<\/jats:styled-content> (four of eight patients), 100% for 99<\/jats:sup>Tc\u2010HYNIC<\/jats:styled-content>\u2010TOC SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> (six of six patients) and 100% for 68<\/jats:sup>Ga\u2010DOTATATE PET<\/jats:styled-content>\/CT<\/jats:styled-content> (seven of seven patients). Of nine patients, six were subjected to both the 99<\/jats:sup>Tc\u2010HYNIC<\/jats:styled-content>\u2010TOC SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> and 68<\/jats:sup>Ga\u2010DOTATATE PET<\/jats:styled-content>\/CT<\/jats:styled-content> and all of them showed coregistration on the two scans.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In patients with pTIO<\/jats:styled-content>, the somatostatin receptor\u2010based functional scans performed better than 18<\/jats:sup>F\u2010FDG PET\/CT in tumour localization. Amongst the somatostatin receptor\u2010based scans, 99<\/jats:sup>Tc\u2010HYNIC<\/jats:styled-content>\u2010TOC SPECT<\/jats:styled-content>\/CT<\/jats:styled-content> and 68<\/jats:sup>Ga\u2010DOTATATE PET<\/jats:styled-content>\/CT<\/jats:styled-content> performed equally well for localization of tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12426","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T09:44:41Z","timestamp":1392630281000},"page":"31-37","source":"Crossref","is-referenced-by-count":57,"title":["Functional imaging in primary tumour\u2010induced osteomalacia: relative performance of FDG PET\/CT vs somatostatin receptor\u2010based functional scans: a series of nine patients"],"prefix":"10.1111","volume":"81","author":[{"given":"Swati","family":"Jadhav","sequence":"first","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kasaliwal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Lele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Jaslok Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Tata Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Jaslok Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Radiation Medicine Centre Bhabha Atomic Research Centre Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha S.","family":"Jagtap","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Budyal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag R.","family":"Lila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Bandgar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology KEM Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1642"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0019"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.9.1108"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-11-0006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010839"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90280-0"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1474-z"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3335"},{"key":"e_1_2_8_11_1","first-page":"e55","article-title":"PET\/CT localisation of a scapular haemangiopericytoma with tumour\u2010induced osteomalacia","volume":"50","author":"Khadgawat R.","year":"2009","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.01.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/58168443"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1881"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP10151.OR"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3642"},{"key":"e_1_2_8_17_1","first-page":"502","article-title":"Internalization of sst2, sst3, and sst5 Receptors: effects of Somatostatin Agonists and Antagonists","volume":"47","author":"Renzo C.","year":"2006","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3282f3a515"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:04:08Z","timestamp":1696392248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,12]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/cen.12426"],"URL":"https:\/\/doi.org\/10.1111\/cen.12426","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,12]]}}}