{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:38:18Z","timestamp":1778567898182,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The General Charities of the City of Coventry"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adipolin\/<jats:styled-content style=\"fixed-case\">CTRP<\/jats:styled-content>12 is a novel adipokine with anti\u2010inflammatory and glucose\u2010lowering properties in rodents. We sought to investigate the effects of metformin treatment (850\u00a0mg twice daily for 6\u00a0months) and a 2\u00a0h 75\u00a0g oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) on serum adipolin concentrations in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study [<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a083) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a039) subjects]. Serum adipolin was measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Metformin treatment (850\u00a0mg twice daily for 6\u00a0months) was offered to all women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, 34 women participated but 21 women completed 6\u00a0months of metformin therapy. Reasons for subjects not completing the study were nausea and gastrointestinal side effects (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), pregnancies (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), noncompliance (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and loss of contact (<jats:italic>n<\/jats:italic>\u00a0=\u00a02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Metformin treatment (850\u00a0mg twice daily for 6\u00a0months) substantially increased serum adipolin concentrations (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b705) in women with polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>), a pro\u2010inflammatory state associated with obesity, diabetes, dyslipidaemia and atherosclerosis. Furthermore, changes in waist\u2010hip ratio, glucose, triglycerides, <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and carotid intima media thickness showed significant negative associations with changes in adipolin levels (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b705, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b701); in multiple regression analyses, only changes in glucose were predictive of changes in adipolin levels (\u03b2\u00a0=\u00a0\u22120\u00b7570, <jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7009). Serum adipolin decreased significantly in response to the <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and control subjects at 90\u00a0min (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b705) and 120\u00a0min (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adipolin and\/or novel pharmacologic agents that increase adipolin's circulating concentrations might constitute a novel approach in the treatment of insulin resistant states.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12438","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:00:15Z","timestamp":1393264815000},"page":"841-846","source":"Crossref","is-referenced-by-count":25,"title":["Circulatory changes of the novel adipokine adipolin\/<scp>CTRP<\/scp>12 in response to metformin treatment and an oral glucose challenge in humans"],"prefix":"10.1111","volume":"81","author":[{"given":"Bee K.","family":"Tan","sequence":"first","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"},{"name":"Department of Obstetrics and Gynaecology Birmingham Heartlands and Solihull Hospitals Heart of England NHS Foundation Trust Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Amar","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harman S.","family":"Mattu","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjunath","family":"Ramanjaneya","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanlata","family":"Patel","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Lehnert","sequence":"additional","affiliation":[{"name":"Warwick Medical School University of Warwick Coventry UK"},{"name":"1<sup>st<\/sup> Medical Department University of L\u00fcbeck Medical School L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpal S.","family":"Randeva","sequence":"additional","affiliation":[{"name":"Warwick Medical School 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