{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:12:27Z","timestamp":1788412347082,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ferring Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Precocious puberty is characterized by early activation of the pituitary\u2010gonadal axis. Oestrogen is the final key factor to start the onset of puberty. The cytochrome P450 19A1 (<jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1) gene encodes an aromatase that is responsible for the conversion of androgens to oestrogen, which is a key step in oestrogen biosynthesis. The aim of this study was to identify <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1 gene mutations or polymorphisms in girls with central precocious puberty (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the frequency of allelic variants of the <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1 exons and the tetranucleotide tandem repeat (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>n<\/jats:sub> in intron 4 in 203 idiopathic central precocious puberty (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>) girls and 101 normal healthy women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype analysis of the <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1 (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>n<\/jats:sub> polymorphism revealed six different alleles ranging from seven to 13 repeats. Among the six different repeat alleles detected in this study, the (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> repeat allele was only detected in the patient group and carriers of the (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> allele were significantly associated with an increased risk of <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01\u00b7509, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01\u00b7425\u20131\u00b7598, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7033). Carriers of the (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> repeat allele were significantly younger at pubertal onset and had higher levels of oestrogen than noncarriers of the (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> repeat allele. Although nine polymorphisms were detected in exons of the <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1 gene, no clinical significance was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, carriers of a higher repeat (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> polymorphism in intron 4 of the <jats:styled-content style=\"fixed-case\">CYP<\/jats:styled-content>19A1 gene had higher levels of oestrogen. Those carrying the (<jats:styled-content style=\"fixed-case\">TTTA<\/jats:styled-content>)<jats:sub>13<\/jats:sub> repeat allele may have a higher risk of developing <jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12439","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:00:16Z","timestamp":1393264816000},"page":"395-400","source":"Crossref","is-referenced-by-count":9,"title":["Association of aromatase (<scp>TTTA<\/scp>)<sub>n<\/sub> repeat polymorphisms with central precocious puberty in girls"],"prefix":"10.1111","volume":"81","author":[{"given":"Hae Sang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ajou University School of Medicine Ajou University Hospital Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ajou University School of Medicine Ajou University Hospital Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Soon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ajou University School of Medicine Ajou University Hospital Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326624"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.08.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1733"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000058374"},{"key":"e_1_2_7_7_1","first-page":"342","article-title":"Aromatase cytochrome P450, the enzyme responsible for estrogen 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