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The aim of this study is to examine gonadotrophin secretion and response to gonadotrophin\u2010releasing hormone (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) in the luteal phase of the menstrual cycle and to investigate the pharmacodynamics and pharmacokinetics of endogenous and exogenous luteinizing hormone (<jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>) in obese women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Participants underwent a luteal phase frequent blood sampling study. Endogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> pulsatility was observed, gonadotrophin\u2010releasing hormone (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) was given in two weight\u2010based doses, and Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> antagonist was administered followed by recombinant <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Regularly menstruating obese (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) and normal weight (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Endogenous hypothalamic\u2010pituitary function (as measured by <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> pulsatility), pituitary sensitivity (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> secretion), pharmacodynamics of endogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and pharmacokinetics of exogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> were compared between the obese and normal weight groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no statistically significant differences in endogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> pulsatility or pituitary responses to two weight\u2010based doses of Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> between the obese and normal weight women. There were no differences in the pharmacodynamics of endogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> or the pharmacokinetics of exogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> between the groups. <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> dynamics did not differ between the groups throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relative hypogonadotrophic hypogonadism of obesity cannot be explained by differences in <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> luteal phase dynamics or differences in endogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> pharmacodynamics or exogenous <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> pharmacokinetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12441","type":"journal-article","created":{"date-parts":[[2014,2,28]],"date-time":"2014-02-28T08:06:41Z","timestamp":1393574801000},"page":"418-425","source":"Crossref","is-referenced-by-count":19,"title":["Luteal phase dynamics of follicle\u2010stimulating and luteinizing hormones in obese and normal weight women"],"prefix":"10.1111","volume":"81","author":[{"given":"Lauren W.","family":"Roth","sequence":"first","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda A.","family":"Allshouse","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L.","family":"Bradshaw\u2010Pierce","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lesh","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Chosich","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kohrt","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Bradford","sequence":"additional","affiliation":[{"name":"Division of Basic Reproductive Sciences University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Polotsky","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanette","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility University of Colorado Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.39"},{"key":"e_1_2_6_3_1","unstructured":"NIH\/NHLBI. 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