{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T19:07:07Z","timestamp":1774465627803,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The clinical phenotype of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) includes reproductive and hormonal aberrations. Visceral adiposity index (<jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content>) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between <jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content>, menstrual disorders and hormonal, biochemical and ultrasound parameters in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred and ninety\u2010three women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosed with Rotterdam criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We correlated <jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content> with metabolic and clinical features of the syndrome and with indices of inflammation and insulin sensitivity. In addition, we classified the patients into four groups according to the severity of menstrual disorders: Group A (<jats:italic>n<\/jats:italic>\u00a0=\u00a042), with severe menstrual disorders, Group B (<jats:italic>n<\/jats:italic>\u00a0=\u00a083), with mild menstrual disorders, Group C (<jats:italic>n<\/jats:italic>\u00a0=\u00a058), without menstrual disorders and Group D (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) with women with sychnominorroia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> studied, <jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content> significantly positively correlated with body weight, fasting glucose, insulin, homeostasis model assessment (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>) score, white blood cells, platelets, uric acid, free testosterone, oestradiol, total cholesterol, \u03b3\u2010<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SGPT<\/jats:styled-content>. Furthermore, a significant inverse correlation between <jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>, Matsuda index and menstrual cycles per year was documented. From the comparison of the four groups, <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women with menstrual disorders had significantly higher <jats:styled-content style=\"fixed-case\">VAI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> indices when compared to <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> without menstrual disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Visceral adiposity index is increased in patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> in concordance with the severity of anovulation, insulin resistance and inflammation. This index could be a very easy and helpful clinical tool in daily practice to predict insulin resistance in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12447","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T05:40:59Z","timestamp":1394170859000},"page":"426-431","source":"Crossref","is-referenced-by-count":36,"title":["Visceral adiposity index (<scp>VAI<\/scp>) is related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"81","author":[{"given":"Ioannis I.","family":"Androulakis","sequence":"first","affiliation":[{"name":"Endocrine Unit Third Department of Internal Medicine Medical School National and Kapodistrian University of Athens Sotiria Hospital Athens 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