{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:39:55Z","timestamp":1790800795991,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["A111345"],"award-info":[{"award-number":["A111345"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["A091224"],"award-info":[{"award-number":["A091224"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korea government","award":["2009-0078222"],"award-info":[{"award-number":["2009-0078222"]}]},{"name":"Korea government","award":["2009-0078234"],"award-info":[{"award-number":["2009-0078234"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to determine which thyroid cancer patients would benefit from <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> in addition to whole\u2010body planar scintigraphy (Rx<jats:styled-content style=\"fixed-case\">WBS<\/jats:styled-content>) for the detection and characterization of I\u2010131 focal uptake after first ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>Neck and thoracic <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content> was performed in 187 patients with I\u2010131 focal uptake suggestive of remnant thyroid tissue (Rem group, <jats:italic>n<\/jats:italic>\u00a0=\u00a0152) or presumed lymph node (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) metastases (m<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> group, <jats:italic>n<\/jats:italic>\u00a0=\u00a035) on Rx<jats:styled-content style=\"fixed-case\">WBS<\/jats:styled-content>. Clinical and pathologic parameters were analysed and compared in patients with and without additional <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content> findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>wIn the Rem group, <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content> revealed additional occult findings on Rx<jats:styled-content style=\"fixed-case\">WBS<\/jats:styled-content> in 13 patients (8\u00b76%). The serum thyroglobulin levels at the time of ablation were significantly higher in patients with additional <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content> findings than in patients without additional findings (4\u00b73\u00a0\u00b1\u00a03\u00b74\u00a0ng\/ml <jats:italic>vs<\/jats:italic> 1\u00b76\u00a0\u00b1\u00a02\u00b77\u00a0ng\/ml, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001). In the m<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> group, <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content> demonstrated only remnant thyroid tissues without evidence of lymph node metastasis in 14 (40\u00b70%) patients, whereas in the remaining 21 (60\u00b70%) patients, I\u2010131 uptake was confirmed in the corresponding neck and mediastinal lymph nodes on <jats:styled-content style=\"fixed-case\">SPECT\/CT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Even in the Rem group, additional <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> could provide useful information for detecting hidden metastasis, especially in patients with high serum thyroglobulin levels. <jats:styled-content style=\"fixed-case\">SPECT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> should be recommended for patients with focal uptake lymph node metastasis on Rx<jats:styled-content style=\"fixed-case\">WBS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12460","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T07:25:50Z","timestamp":1397114750000},"page":"445-451","source":"Crossref","is-referenced-by-count":34,"title":["Clinical applications of <scp>SPECT<\/scp>\/<scp>CT<\/scp> after first I\u2010131 ablation in patients with differentiated thyroid cancer"],"prefix":"10.1111","volume":"81","author":[{"given":"Shin Young","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Kyungpook National University Medical Center and School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Kyungpook National University Medical Center and School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Kyungpook National University Medical Center and School of Medicine Daegu Korea"},{"name":"Department of Nuclear Medicine Keimyung University School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong\u2010Il","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Kyungpook National University Medical Center and School of Medicine Daegu Korea"},{"name":"Department of Nuclear Medicine Keimyung University School of Medicine Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong\u2010Cheol","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Kyungpook National University Medical Center and 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