{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:44:51Z","timestamp":1791571491893,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n We aimed to investigate whether fasting and meal regulated glucagon like peptide 1 (\n GLP<\/jats:styled-content>\n \u20101) secretion are altered in patients with polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ) compared to healty women and whether oral contraceptive use influence\n GLP<\/jats:styled-content>\n \u20101 secretion dynamics in the syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Patients<\/jats:title>\n \n Fourteen lean normal glucose tolerant patients with\n PCOS<\/jats:styled-content>\n and 11 age\u2010 and body mass index (\n BMI<\/jats:styled-content>\n )\u2010matched healthy women.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Glucagon like peptide 1, glucose and insulin levels were measured during a standardized meal tolerance test and area under the curves (\n AUC<\/jats:styled-content>\n s) were calculated. Whereas healthy controls were assessed at baseline, all tests were repeated in women with\n PCOS<\/jats:styled-content>\n after treatment with ethinyl estradiol 30\u00a0\u03bcg\/drospirenone 3\u00a0mg (\n EE<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n ) for 3\u00a0months.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both fasting and post\u2010meal levels of\n GLP<\/jats:styled-content>\n \u20101 were significantly reduced in women with\n PCOS<\/jats:styled-content>\n compared to controls (\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7022 and\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7028, respectively).\n AUC<\/jats:styled-content>\n for\n GLP<\/jats:styled-content>\n \u20101 was also lower in\n PCOS<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7012). Glucose and insulin measurements did not show a significant change between the groups. In the\n PCOS<\/jats:styled-content>\n group,\n GLP<\/jats:styled-content>\n \u20101, glucose and insulin levels did not show any change after 3\u00a0months of\n EE<\/jats:styled-content>\n \/\n DRSP<\/jats:styled-content>\n use.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n GLP<\/jats:styled-content>\n \u20101 levels both at fasting and in response to a meal are blunted in lean women with\n PCOS<\/jats:styled-content>\n compared to healthy women. Short term oral contraception do not alter\n GLP<\/jats:styled-content>\n \u20101 secretion in\n PCOS<\/jats:styled-content>\n . Disturbance in incretin secretion dynamics might contribute to the risk of impaired glucose tolerance and type 2 diabetes in\n PCOS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12468","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T05:06:45Z","timestamp":1397538405000},"page":"588-592","source":"Crossref","is-referenced-by-count":34,"title":["Fasting and post\u2010prandial glucagon like peptide 1 and oral contraception in polycystic ovary syndrome"],"prefix":"10.1111","volume":"81","author":[{"given":"Kadriye","family":"Aydin","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcan","family":"Arusoglu","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Hacettepe University School of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulden","family":"Koksal","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Hacettepe University School of Health Sciences Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nese","family":"Cinar","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Yazgan Aksoy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Etlik Ihtisas Research and Training Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent O.","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Hacettepe University School of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-63-2-492"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220405"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370127"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.3.525"},{"issue":"3","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/000456329603300303","article-title":"The entero\u2010insular axis in polycystic ovarian syndrome","volume":"33","author":"Gama R.","year":"1996","journal-title":"Annals of clinical 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