{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:14:21Z","timestamp":1772579661244,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T00:00:00Z","timestamp":1400457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Population iodine status can be assessed by urinary iodine concentrations, prevalence of goitre, frequency of newborn thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) &gt;5\u00a0mU\/l and blood thyroglobulin concentrations. The UK population has historically been considered to be iodine sufficient; however, a recent survey of UK schoolgirls has demonstrated median urinary iodine concentrations consistent with mild iodine deficiency. The aim of our study was to assess the prevalence of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> &gt;5\u00a0mU\/l in the newborn blood spot screening samples from the eligible population in Wales between 2011 and 2013 to assess iodine sufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Blood spot <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> data for 104\u00a0992 infants during this time period were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> &gt;5\u00a0mU\/l in samples collected on days 4 and 5 of life were 1\u00b75% and 0\u00b79%, respectively. No increasing trend in blood spot <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> concentration was identified over the 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The distribution of blood spot <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> data from neonates in Wales has revealed no evidence to support the hypothesis that the population is iodine deficient. However, given that mild iodine deficiency has been reported in a cohort that will be childbearing in the next decade, we recommend that the distribution of neonatal blood spot <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> concentrations is monitored by the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> newborn screening programmes to identify any emerging trends in iodine status. Further studies to correlate maternal urinary iodine and newborn blood spot <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> are required to clarify the <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> cut\u2010off points associated with mild iodine deficiency relevant to the time of blood spot sampling in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12474","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T11:02:58Z","timestamp":1399374178000},"page":"606-609","source":"Crossref","is-referenced-by-count":15,"title":["Neonatal blood <scp>TSH<\/scp> concentration in Wales (<scp>UK<\/scp>): an indicator of iodine sufficiency"],"prefix":"10.1111","volume":"81","author":[{"given":"Carol","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Immunology University Hospital of Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Barry Nix","sequence":"additional","affiliation":[{"name":"Department of General Practice and Public Health University of Cardiff, University Hospital of Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Hillier","sequence":"additional","affiliation":[{"name":"Screening Division Public Health Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Moat","sequence":"additional","affiliation":[{"name":"Wales Newborn Screening Laboratory Department of Medical Biochemistry and Immunology University Hospital of Wales Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0011"},{"key":"e_1_2_7_3_1","volume-title":"Assessment of Iodine Deficiency Disorders and Monitoring their Elimination","author":"WHO","year":"2007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61005-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1994.4.107"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.51.4.391"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60693-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04168.x"},{"key":"e_1_2_7_9_1","unstructured":"Food Standards Agency.Retail survey of iodine in UK produced dairy foods. 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January 2013.www.newbornbloodspot.screening.nhs.uk\/cht(accessed 8\/10\/13)."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047770"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2002.tb04431.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.08.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/ajcn\/82.2.388","article-title":"Increasing the iodine concentration in the Swiss iodized salt program markedly improved iodine status in pregnant women and children, a 5\u2010y prospective national study","volume":"82","author":"Zimmerman M.B.","year":"2005","journal-title":"American Journal of Clinical Nutrition"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.05.019"},{"key":"e_1_2_7_17_1","unstructured":"Live Births by Year and Age of Mother. 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