{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:39Z","timestamp":1761519099370},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The distinction between corticotropin (<jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>)\u2010producing pituitary adenomas and occult ectopic <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> neoplasms is a challenge and frequently complicated by the detection of nonfunctioning pituitary adenomas on dynamic magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">DMRI<\/jats:styled-content>). Herein, we explored quantitative differences in <jats:styled-content style=\"fixed-case\">DMRI<\/jats:styled-content> measures from <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing pituitary adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Fifty\u2010five patients with pathology confirmed <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing and 44 with nonfunctioning pituitary adenomas were analysed in this retrospective pilot study. The intensities of adenomas and of adjacent pituitary tissue were measured by drawing a region of interest. Time\u2013intensity curves were then constructed, and quantitative analysis included: enhancement time, enhancement peak and prepeak slope (<jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content>). Multivariable logistic analysis and receiver operating characteristic curves (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) were used to evaluate the parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative analysis showed that tumour <jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing adenomas was markedly lower than that in nonfunctioning adenomas (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70042) and that the <jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content> of the adjacent pituitary gland was not different (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b72441). The <jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content> was &gt;3\u00b70 in 59\u00b71% of nonfunctioning adenomas and \u22643\u00b70 in 69\u00b71% of <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing adenomas (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70049). Logistic analysis revealed lower tumour <jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content> levels (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70123, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1\u00b724, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b705\u20131\u00b752) were associated with <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing adenomas. The optimal <jats:styled-content style=\"fixed-case\">PPS<\/jats:styled-content> cut\u2010off determined by <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> analysis was 2\u00b789, with a sensitivity of 69% and specificity of 70%. No significant difference was found between the two groups in enhancement time or enhancement peak.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enhancement parameters in <jats:styled-content style=\"fixed-case\">DMRI<\/jats:styled-content> can help distinguishing <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> producing from nonfunctioning pituitary adenomas, which could be useful in the differential diagnosis between <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010producing pituitary adenomas and ectopic <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> syndrome complicated with nonfunctioning pituitary adenoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12475","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T11:02:56Z","timestamp":1399374176000},"page":"267-273","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of dynamic <scp>MRI<\/scp> enhancement measures for the diagnosis of <scp>ACTH<\/scp>\u2010producing pituitary adenomas"],"prefix":"10.1111","volume":"82","author":[{"given":"Qinghua","family":"Guo","sequence":"first","affiliation":[{"name":"Division of Endocrinology Chinese PLA General Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition Mayo Medical School Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Erickson","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nutrition Mayo Medical School Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Medical School Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"137","article-title":"The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism)","volume":"50","author":"Cushing H.W.","year":"1932","journal-title":"Bulletin of the Johns Hopkins Hospital"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302007000800006"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.01.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-001-0032-5"},{"key":"e_1_2_5_6_1","first-page":"278","article-title":"Cushing's disease: establishing the diagnosis and management approach","volume":"61","author":"Varadhan L.","year":"2013","journal-title":"The Journal of the Association of Physicians of India"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0337"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13171.OR"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.10.011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.10.009"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0627"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2527"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68699-6"},{"key":"e_1_2_5_14_1","first-page":"132","article-title":"The role of bilateral inferior petrosal sinus sampling in the diagnostic evaluation of Cushing syndrome","volume":"18","author":"Deipolyi A.","year":"2012","journal-title":"Diagnostic and Interventional Radiology"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343772"},{"key":"e_1_2_5_16_1","first-page":"306","article-title":"Venous subarachnoid hemorrhage after inferior petrosal sinus sampling for adrenocorticotropic hormone","volume":"20","author":"Bonelli F.S.","year":"1999","journal-title":"AJNR. 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