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These neoplasms are defined as gastric<jats:styled-content style=\"fixed-case\">NEN<\/jats:styled-content>s type 1 (<jats:styled-content style=\"fixed-case\">GNEN<\/jats:styled-content>1) and have recently been shown to constitute the commonest<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NEN<\/jats:styled-content>s in a prospective study. GNEN1s are usually multiple and follow a relative indolent course, raising questions regarding the extent that such patients should be investigated and the appropriate therapeutic interventions needed. Recently, a number of consensus statements and guidelines have been published from various societies dealing with the diagnosis and management of<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NEN<\/jats:styled-content>s. Endocrinologists are among the many different medical specialties involved in GNEN1s diagnosis and management. However, despite recent advances, few randomized trials are available, and thus existing evidence remains relatively weak compared to other malignancies. The purpose of this review is to provide recent evidence along with currently employed modalities addressing the diagnosis, management, long\u2010term follow\u2010up and potential comorbidities of<jats:styled-content style=\"fixed-case\">GNEN<\/jats:styled-content>1s.<\/jats:p>","DOI":"10.1111\/cen.12476","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T10:21:07Z","timestamp":1397902867000},"page":"157-168","source":"Crossref","is-referenced-by-count":25,"title":["Current concepts in the diagnosis and management of type 1 gastric neuroendocrine neoplasms"],"prefix":"10.1111","volume":"81","author":[{"given":"Gregory","family":"Kaltsas","sequence":"first","affiliation":[{"name":"Department of Pathophysiology National University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Grozinsky\u2010Glasberg","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumor Unit Endocrinology and Metabolism Service Department of Medicine Hadassah\u2010Hebrew University Hospital Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystallenia I.","family":"Alexandraki","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology National University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology National University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos V.","family":"Tsolakis","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Section of Endocrine Oncology Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gross","sequence":"additional","affiliation":[{"name":"Neuroendocrine Tumor Unit Endocrinology and Metabolism Service Department of Medicine Hadassah\u2010Hebrew University Hospital Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley B.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Oxford Centre for Diabetes, Endocrinology and Metabolism University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0014"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572-0241.2003.04027.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1699-0463.1976.tb00122.x","article-title":"Carcinoid tumours. 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