{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:37:34Z","timestamp":1769553454775,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The pathogenesis of parathyroid tumours is only partially understood. A direct approach using proteomics could be a promising tool to increase our understanding of parathyroid tumorigenesis. The aim of the study was to investigate differentially expressed proteins to explore the underlying molecular basis of the disease and identify potential target proteins responsible for the genesis of adenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Proteins were extracted from adenomatous and normal parathyroid tissues. Differentially expressed proteins were separated by two\u2010dimensional gel electrophoresis (2\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>) and identified by matrix\u2010assisted laser desorption\/ionization\u2010time of flight (<jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>) mass spectrometry. Statistical analysis was performed using <jats:sc>spss<\/jats:sc> 10.01 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparative analysis of the 2\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> profiles of proteins isolated from adenomatous and normal parathyroid tissues showed 15 differentially expressed proteins, of which 11 were overexpressed. The characterized proteins were associated with diverse cellular functions including regulation of cell organization, programmed cell death, transcription and signal transduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The differentially expressed proteins in parathyroid adenomas may potentially serve as new targets to investigate the mechanisms of parathyroid adenoma transformation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12479","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T13:24:43Z","timestamp":1398432283000},"page":"614-620","source":"Crossref","is-referenced-by-count":13,"title":["Changes in parathyroid proteome in patients with primary hyperparathyroidism due to sporadic parathyroid adenomas"],"prefix":"10.1111","volume":"81","author":[{"given":"Shweta","family":"Varshney","sequence":"first","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh Kumar","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunanshu","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of General Surgery Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhaker D.","family":"Rao","sequence":"additional","affiliation":[{"name":"Bone &amp; 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