{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:01:32Z","timestamp":1761102092188,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aortic abnormalities contribute to increased morbidity and mortality of women with Turner syndrome (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>). Impaired aortic stiffness may prove to have clinical prognostic value in <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> as is the case in other diseases such as Marfan syndrome, diabetes and hypertension. Additionally, the parental origin of the X chromosome in <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> may influence aortic stiffness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the relation between X chromosome parental origin and aortic stiffness in <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four subjects with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> participated in this cross\u2010sectional study at a tertiary care centre. The parental origin of the X chromosome was determined. Cardiac\u2010gated multidetector computerized tomography (<jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content>) was performed and distensibility of the ascending aorta (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>), a measure of aortic stiffness, was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen women were Xm (maternal origin) and 10 were Xp (paternal origin) for their inheritance of the single X chromosome. Age, body size, blood pressure and <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> areas were similar in the two groups. However, the calculated <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> distensibility was significantly lower in the Xm group (2\u00b78\u00a0\u00b1\u00a01\u00b71\u00a0mm\/Hg) than in the Xp group (4\u00b71\u00a0\u00b1\u00a01\u00b75\u00a0mm\/Hg); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> This study demonstrates that <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> subjects that inherit their single X chromosome from their mother (Xm) have a significantly stiffer aorta compared with the <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> with a paternally originating X chromosome (Xp), consistent with a potentially greater risk for cardiovascular complications. These findings suggest that parental chromosomal analysis and aortic stiffness measurements would be useful for the risk assessment and clinical management of <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12481","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T20:51:42Z","timestamp":1399323102000},"page":"467-470","source":"Crossref","is-referenced-by-count":10,"title":["X chromosome parental origin and aortic stiffness in turner syndrome"],"prefix":"10.1111","volume":"81","author":[{"given":"Khaled Z.","family":"Abd\u2010Elmoniem","sequence":"first","affiliation":[{"name":"Biomedical and Metabolic Imaging Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir K.","family":"Bakalov","sequence":"additional","affiliation":[{"name":"Section on Developmental Epigenetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin R.","family":"Matta","sequence":"additional","affiliation":[{"name":"Biomedical and Metabolic Imaging Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Muldoon","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Clinical Center National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Hanover","sequence":"additional","affiliation":[{"name":"Laboratory of Cell and Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn A.","family":"Bondy","sequence":"additional","affiliation":[{"name":"Section on Developmental Epigenetics Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Biomedical and Metabolic Imaging Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 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