{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:21:57Z","timestamp":1793283717064,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Summary<\/jats:title>Background and Objectives<\/jats:title>Recently, the Indian Council of Medical Research (ICMR<\/jats:styled-content>) has published normative data for bone mineral density (BMD<\/jats:styled-content>) measured by dual\u2010energy X\u2010ray absorptiometry (DXA<\/jats:styled-content>) scanning. However, the impact this has had on the diagnosis of osteoporosis when compared to currently used Caucasian databases has not been analysed. Hence, this study was undertaken to look at agreement between the Hologic Database (HD<\/jats:styled-content>) based on BMD<\/jats:styled-content> normative data in Caucasians and the ICMR<\/jats:styled-content> database (ICMRD<\/jats:styled-content>) in defining osteoporosis in subjects with or without hip fracture.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>It is a cross \u2010sectional study of 2976 subjects (men 341, women 2757) (mean age\u00a0\u00b1\u00a0SD\u00a0=\u00a062\u00b72\u00a0\u00b1\u00a07\u00b72\u00a0years), including 316 subjects with low impact hip fracture: 2199 were from the hospital database, and 461 were healthy postmenopausal women from the community who underwent (DXA<\/jats:styled-content>) scanning between January 2010 and March 2013. Recalculated T<\/jats:italic> scores from ICMRD<\/jats:styled-content> were used for the diagnosis of osteoporosis and compared with HD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>An almost perfect agreement existed between the two databases for the diagnosis of osteoporosis at the hip (\u03ba \u22120\u00b782, P<\/jats:italic>\u00a0<\u00a00\u00b70001) in all subjects, and a moderate relationship existed in those with hip fracture (\u03ba \u22120\u00b765, P<\/jats:italic>\u00a0<\u00a00\u00b70001). Seventy\u2010three of 316 hip fracture subjects (23\u00b75%) defined as osteoporosis according to HD<\/jats:styled-content> were classified as osteopenia according to ICMRD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The threshold of hip BMD<\/jats:styled-content>T<\/jats:italic> score for treating osteoporosis may have to be redefined if the ICMR<\/jats:styled-content> reference database is used. Initiation of treatment in these subjects must be based on multiple fracture risk factor assessment in addition to looking at BMD<\/jats:styled-content>. Further studies with a larger sample size of subjects with fracture are needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12495","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T06:42:35Z","timestamp":1399963355000},"page":"519-522","source":"Crossref","is-referenced-by-count":15,"title":["The impact of the Hologic vs<\/i> the ICMR<\/scp> database in diagnosis of osteoporosis among South Indian subjects"],"prefix":"10.1111","volume":"81","author":[{"given":"Sahana","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dukhabandhu","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesarghatta S","family":"Asha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Christian Medical College Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Osteoporosis Foundation Releases New Data Detailing the Prevalence of Osteoporosis. Available from:http:\/\/nof.org\/news\/nofnews\/2011-0510-AdvocacyNews(accessed 13 April 2013)."},{"key":"e_1_2_6_3_1","unstructured":"Handa R.(2003)Action Plan Osteoporosis: Consensus Statement of the Expert Group Meeting Osteoporosis Society of India. New Delhi.1\u201340. Available from:http:\/\/www.osteofound.org\/press_centre\/fact_sheet.html(accessed 26 June 2012)."},{"key":"e_1_2_6_4_1","first-page":"263","article-title":"Osteoporosis in Indians","volume":"127","author":"Malhotra N.","year":"2008","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/2230-8210.104115","article-title":"Postmenopausal osteoporosis: our experience","volume":"16","author":"Mehrotra R.N.","year":"2012","journal-title":"Indian Journal of Endocrinology and Metabolism"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050093"},{"key":"e_1_2_6_7_1","first-page":"21","article-title":"A Population based reference standards of peak bone mineral density of Indian males and females","volume":"8","author":"Mukherjee A.","year":"2011","journal-title":"ICMR Bulletin"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.73656"},{"key":"e_1_2_6_9_1","first-page":"337","article-title":"Current understanding of osteoporosis according to the position of the World Health Organization (WHO) and International Osteoporosis Foundation","volume":"9","author":"Czerwinski E.","year":"2007","journal-title":"Ortopedia, Traumatologia, Rehabilitacja"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-008-0019-z"},{"key":"e_1_2_6_11_1","first-page":"757102","article-title":"Geographic variation in osteoporotic hip fracture incidence: the growing importance of Asian influences in coming decades","volume":"2","author":"Dhanwal D.K.","year":"2010","journal-title":"Journal of Osteoporosis"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2010.05.007"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12495","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:12:51Z","timestamp":1695535971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/cen.12495"],"URL":"https:\/\/doi.org\/10.1111\/cen.12495","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,17]]}}}