{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T21:21:42Z","timestamp":1696540902035},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T00:00:00Z","timestamp":1402531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) is sometimes unmasked after unilateral adrenalectomy in patients with primary aldosteronism (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>) without expectation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our study aim was to elucidate factors responsible for developing postoperative <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> and to provide a simple scoring system to predict postoperative <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>Forty\u2010five patients with PA treated with unilateral adrenalectomy and followed for at least 1\u00a0month postsurgery were studied. Thirty\u2010one patients with non\u2010PA adrenal disease who underwent unilateral adrenalectomy were also studied as control. Patients with pre\u2010operative estimated glomerular filtration rate (e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>)\u00a0&lt;\u00a060\u00a0ml\/min\/1\u00b773 m<jats:sup>2<\/jats:sup> were excluded from both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) decrease in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> was observed in PA group within 1\u00a0month of surgery, then stabilized. Of the 45 patients with PA, 17 (37\u00b78%) developed CKD after surgery. None of the non\u2010PA group developed CKD after surgery. Of the pre\u2010operative variables, logistic regression analysis showed that lower <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> and higher aldosterone\u2010to\u2010renin ratios (ARR) were the independent predictors for postoperative CKD in PA. Optimal cut\u2010off values of the two variables analysed with ROC curves were as follows: e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>\u00a0\u2264\u00a076\u00b79\u00a0ml\/min\/1\u00b773\u00a0m<jats:sup>2<\/jats:sup> and ARR\u00a0\u2265\u00a0305. Using these data, we created a CKD score as a tool for predicting postoperative CKD, with an AUC for the score of 0\u00b78866.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pre\u2010operative e<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> and ARR were the significant contributing factors for postoperative CKD in PA. By combining these independent factors, we created a CKD score which provides useful information before surgery about the risk for development of postoperative CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12497","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T06:42:41Z","timestamp":1399963361000},"page":"665-670","source":"Crossref","is-referenced-by-count":17,"title":["Chronic kidney disease score for predicting postoperative masked renal insufficiency in patients with primary aldosteronism"],"prefix":"10.1111","volume":"81","author":[{"given":"Kanako","family":"Tanase\u2010Nakao","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhide","family":"Naruse","sequence":"additional","affiliation":[{"name":"Clinical Research Institute National Hospital Organization Kyoto Medical Center 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