{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T10:43:27Z","timestamp":1744627407654},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Project (Ministry of Health, Czech Republic) for Conceptual Development of Research Organization 00064203 (University Hospital Motol, Prague, Czech Republic)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although hypogonadism and <jats:italic>SHOX<\/jats:italic> gene haploinsufficiency likely cause the decreased bone mineral density and increased fracture rate associated with Turner syndrome (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>), the exact mechanism remains unclear. We tested the hypothesis that muscle dysfunction in patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> contributes to increased fracture risk. The secondary aim was to determine whether menarche, hormone therapy duration, positive fracture history and genotype influence muscle function parameters in patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study was conducted in a single university hospital referral centre between March 2012 and October 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Sixty patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> (mean age of 13\u00b77\u00a0\u00b1\u00a04\u00b75\u00a0years) were compared to the control group of 432 healthy girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>A Leonardo Mechanograph<jats:sup>\u00ae<\/jats:sup> Ground Reaction Force Platform was used to assess muscle force (<jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub>) by the multiple one\u2010legged hopping test and muscle power (<jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub>) by the single two\u2010legged jump test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While the <jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub> was normal (mean weight\u2010specific <jats:italic>Z<\/jats:italic>\u2010score of 0\u00b711\u00a0\u00b1\u00a00\u00b777, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b727), the <jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub> was decreased in patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> (<jats:italic>Z<\/jats:italic>\u2010score of \u22120\u00b793\u00a0\u00b1\u00a01\u00b75, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) compared with healthy controls. The muscle function parameters were not significantly influenced by menarcheal stage, hormone therapy duration, fracture history or genotype (linear regression adjusted for age, weight and height; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00\u00b705 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>F<\/jats:italic><jats:sub>max<\/jats:sub>, a principal determinant of bone strength, is normal in patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>. Previously described changes in bone quality and structure in <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> are thus not likely related to inadequate mechanical loading but rather represent a primary bone deficit. A decreased <jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub> indicates impaired muscle coordination in patients with <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12518","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T09:25:07Z","timestamp":1401701107000},"page":"248-253","source":"Crossref","is-referenced-by-count":10,"title":["Muscle function in Turner syndrome: normal force but decreased power"],"prefix":"10.1111","volume":"82","author":[{"given":"Ondrej","family":"Soucek","sequence":"first","affiliation":[{"name":"Department of Paediatrics 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lebl","sequence":"additional","affiliation":[{"name":"Department of Paediatrics 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Matyskova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Snajderova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislava","family":"Kolouskova","sequence":"additional","affiliation":[{"name":"Department of Paediatrics 2nd Faculty of Medicine Charles University in Prague and Motol University Hospital Prague Czech 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