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Identifying predictors of <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> is paramount to the long\u2010term management of these patents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study was conducted of patients with treated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. Patients completed a medical history questionnaire and three validated quality of life assessments: <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ushing's <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L Q<\/jats:styled-content>uestionnaire (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ushing<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nxiety and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epression <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cale (<jats:styled-content style=\"fixed-case\">HADS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ottingham <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rofile (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>102 patients (75\u00b77% female, mean time since surgery 7\u00b74\u00a0years) with treated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Patients were categorized by biochemical and self\u2010identified disease status. Mean <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ushing<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, anxiety and depression scores were compared by unpaired <jats:italic>t<\/jats:italic>\u2010tests. Multiple linear regressions were performed on the whole cohort to assess for predictors of impaired <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010two per cent of the cohort met criteria for biochemical remission, but only 80\u00b74% felt they had achieved remission. Among those with biochemical remission, those who also self\u2010identified as being in remission had higher <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ushing<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> scores than those who self\u2010identified as having persistent disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7042). Anxiety (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7032) and depression (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018) scores were lower, and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ushing<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>oL scores were higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705) in patients who self\u2010identified as being in remission compared to persistence. Recovery time, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, gender and age were also predictors for <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study identifies the discordance that can exist between biochemical and self\u2010assessed disease status and demonstrates its impact on <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. These findings highlight the importance of incorporating patients' disease perceptions in their management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12521","type":"journal-article","created":{"date-parts":[[2014,6,13]],"date-time":"2014-06-13T16:13:12Z","timestamp":1402675992000},"page":"404-411","source":"Crossref","is-referenced-by-count":24,"title":["Predictors of quality of life in 102 patients with treated <scp>C<\/scp>ushing's disease"],"prefix":"10.1111","volume":"82","author":[{"given":"Alessia","family":"Carluccio","sequence":"first","affiliation":[{"name":"Department of Medicine The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina K.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Medicine and Endocrinology The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumedha","family":"Chablani","sequence":"additional","affiliation":[{"name":"Department of Medical Education The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levana G.","family":"Amrock","sequence":"additional","affiliation":[{"name":"Department of Medical Education The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica K.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Medicine and Endocrinology The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalmon D.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza B.","family":"Geer","sequence":"additional","affiliation":[{"name":"Department of Medicine and Endocrinology The Icahn School of Medicine at Mount Sinai New York NY USA"},{"name":"Department of Neurosurgery The Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321207"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.5.647"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1375"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075538"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.1949"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00059-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0512"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03288.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0308"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-013-0012-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2893"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0762"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.34.4.281"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2734"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018810380214"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3123"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1042-3680(02)00031-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.6.980"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0766"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04055.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdi025"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03169.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00233.x"},{"key":"e_1_2_8_26_1","first-page":"53","article-title":"Gender differences in health\u2010related quality of life among postmyocardial infarction patients: brief report. 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