{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:17:01Z","timestamp":1783030621693,"version":"3.54.6"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["NO1-AG-1-2109"],"award-info":[{"award-number":["NO1-AG-1-2109"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thyroid dysfunction may accelerate atherosclerosis. Aortic pulse wave velocity (PWV) is an early index of arterial stiffness and an important risk factor for cardiovascular disease and might therefore be linked to changes in thyroid activity. We investigated the relationship between thyroid function and carotid\u2010femoral PWV, as an index of arterial stiffness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Participants from the Sardi<jats:styled-content style=\"fixed-case\">NIA<\/jats:styled-content> study. Those being treated for thyroid diseases were excluded, yielding a sample of 5875 aged 14\u2013102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Clinical parameters, blood tests including serum <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and serum <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4, and carotid\u2010femoral PWV were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for confounders, a direct and linear association between <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 and PWV was shown (multiple regression analysis). The model containing age, mean blood pressure, body mass index, heart rate, <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4, hypertension, diabetes and dyslipidaemia accounted for 55% of the variation in PWV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Like several other known risk factors, serum <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 levels are associated with carotid\u2010femoral PWV, suggesting that high <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 levels have a detrimental effect on aortic stiffness and may contribute to ageing process of the vascular system. This finding may help to understand the pathogenesis of cardiovascular disease and contribute to improve prevention therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12532","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T16:21:53Z","timestamp":1403540513000},"page":"592-597","source":"Crossref","is-referenced-by-count":37,"title":["Serum free thyroxine levels are positively associated with arterial stiffness in the Sardi<scp>NIA<\/scp> study"],"prefix":"10.1111","volume":"82","author":[{"given":"Alessandro P.","family":"Delitala","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine Azienda Ospedaliero\u2010Universitaria di Sassari Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Orr\u00f9","sequence":"additional","affiliation":[{"name":"Istituto di Ricerca Genetica e Biomedica (IRGB) Consiglio Nazionale delle Ricerche c\/o Cittadella Universitaria di Monserrato 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