{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:40Z","timestamp":1787014000476,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T00:00:00Z","timestamp":1406246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n The performance of late\u2010night salivary cortisol (\n LNSC<\/jats:styled-content>\n ) to accurately screen for postoperative recurrence of Cushing's disease (\n CD<\/jats:styled-content>\n ) at an early stage is unknown. The aim of this study was to compare the accuracy of multiple sampling strategies to suggest the optimal number of\n LNSC<\/jats:styled-content>\n samples needed for diagnosing post\u2010surgical recurrences of\n CD<\/jats:styled-content>\n at an early stage.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective analysis in a single centre.<\/jats:p>\n <\/jats:sec>\n \n Patients and measurements<\/jats:title>\n \n Thirty\u2010six patients in surgical remission of\n CD<\/jats:styled-content>\n had successive measurements of\n LNSC<\/jats:styled-content>\n , defined as \u2018sequences\u2019, using a locally modified\n RIA<\/jats:styled-content>\n assay as part of long\u2010term follow\u2010up (69\u00b72\u00a0\u00b1\u00a010\u00b76\u00a0months). Patients underwent an extensive biochemical evaluation within 3\u00a0months before or after a sequence of saliva sampling and were classified as being in remission or in early\u2010stage recurrence. The accuracy of three diagnostic strategies combining two, three or four\n LNSC<\/jats:styled-content>\n results from a sequence was estimated using areas under the\n ROC<\/jats:styled-content>\n curves (\n AUC<\/jats:styled-content>\n ), sensitivity, specificity and predictive values.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010four sequences of\n LNSC<\/jats:styled-content>\n measurements were available. Fifty\u2010two percent of sequences were performed during early\u2010stage recurrence. The intrasequence variability of\n LNSC<\/jats:styled-content>\n was higher during recurrence than during remission (medians of\n SD<\/jats:styled-content>\n s: 2\u00b71\n vs<\/jats:italic>\n 0\u00b75\u00a0n\n m<\/jats:sc>\n ;\n P<\/jats:italic>\n \u00a0<\u00a00\u00b70001).\n AUC<\/jats:styled-content>\n s from\n ROC<\/jats:styled-content>\n curves ranged from 0\u00b793 to 0\u00b796 depending on the strategy. For 90% sensitivities, the best specificities (92\u00b79% and 90\u00b79%) were achieved by strategies taking into account three or four measurements summarized either by their mean or their maximum value.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Increase in\n LNSC<\/jats:styled-content>\n concentration is an early abnormality during post\u2010surgical recurrence of\n CD<\/jats:styled-content>\n . However, due to a major within\u2010patient variability of\n LNSC<\/jats:styled-content>\n from 1\u00a0day to another, a screening strategy using three or four samples collected on successive days may be recommended to detect early\u2010stage recurrence of\n CD<\/jats:styled-content>\n with a high accuracy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.12534","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T12:19:03Z","timestamp":1403785143000},"page":"260-266","source":"Crossref","is-referenced-by-count":35,"title":["Accuracy of repeated measurements of late\u2010night salivary cortisol to screen for early\u2010stage recurrence of\n C<\/scp>\n ushing's disease following pituitary surgery"],"prefix":"10.1111","volume":"82","author":[{"given":"Marie","family":"Danet\u2010Lamasou","sequence":"first","affiliation":[{"name":"Departement d'Endocrinologie et Maladies Metaboliques CHU de Bordeaux, Hopital du Haut Leveque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Asselineau","sequence":"additional","affiliation":[{"name":"USMR University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Perez","sequence":"additional","affiliation":[{"name":"USMR University of Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Vivot","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux P\u00f4le de sant\u00e9 publique Service d'information m\u00e9dicale 1 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Nunes","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie et Maladies Metaboliques CHU de Bordeaux, Hopital du Haut Leveque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Loiseau","sequence":"additional","affiliation":[{"name":"CHU of Bordeaux Department of Neurosurgery Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"San\u2010Galli","sequence":"additional","affiliation":[{"name":"CHU of Bordeaux Department of Neurosurgery Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Cherifi\u2010Gatta","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie et Maladies Metaboliques CHU de Bordeaux, Hopital du Haut Leveque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Beno\u00eet","family":"Corcuff","sequence":"additional","affiliation":[{"name":"CHU of Bordeaux Department of Nuclear Medecine Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"Departement d'Endocrinologie et Maladies Metaboliques CHU de Bordeaux, Hopital du Haut Leveque Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2734"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0424"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.12"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2234"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.12.5695"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1171"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1166"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-011-0333-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0125"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03381.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0159"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1542"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0424"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0485"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0803"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9597-z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12259"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2458"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04508.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0710"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030751"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3569"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77244-8"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-1095"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.8.2664"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00299-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2893"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0320"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2722"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1163"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0596"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02717.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2264"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2861"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12534","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:22:39Z","timestamp":1695550959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/cen.12534"],"URL":"https:\/\/doi.org\/10.1111\/cen.12534","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]}}}