{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:01:33Z","timestamp":1774126893005,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T00:00:00Z","timestamp":1407456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies report impaired health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) in patients with functional pituitary adenomas (<jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content>). We assessed <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in <jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content> patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study including a large control population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL was assessed by the 15D in 100 <jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content> patients (acromegaly <jats:italic>n<\/jats:italic>\u00a0=\u00a047, Cushing's disease <jats:italic>n<\/jats:italic>\u00a0=\u00a021, prolactinoma <jats:italic>n<\/jats:italic>\u00a0=\u00a026, <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>\u2010adenoma <jats:italic>n<\/jats:italic>\u00a0=\u00a02, gonadotropinoma <jats:italic>n<\/jats:italic>\u00a0=\u00a04), operated on a mean 7\u00b74 (range 2\u00b71\u201313\u00b70) years earlier. An age\u2010 and gender\u2010standardized sample of the general population (<jats:italic>n<\/jats:italic>\u00a0=\u00a04924) served as controls. <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL determinants were assessed by independent samples <jats:italic>t<\/jats:italic>\u2010test and multiple regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hormonal remission rate was 90\u00b79% and 43\u00b79% of the patients received replacement therapy. The mean 15D scores were similar in patients and controls (0\u00b7917 <jats:italic>vs<\/jats:italic> 0\u00b7922, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7568). On single dimensions, patients were worse off regarding speech and sexual activity (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) and better off regarding discomfort and symptoms (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), co\u2010morbidities (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009), Cushing's disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7034), and thyroxine dose (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002) predicted impaired <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL, but not hypopituitarism, hydrocortisone replacement, radiotherapy, or time after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is possible to achieve near\u2010normal <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in surgically treated <jats:styled-content style=\"fixed-case\">FPA<\/jats:styled-content> patients given adjuvant treatment to achieve strict hormonal remission. However, in addition to age and co\u2010morbidities, Cushing's disease and need for thyroxine replacement therapy predict impaired <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12550","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T16:13:11Z","timestamp":1405008791000},"page":"412-421","source":"Crossref","is-referenced-by-count":18,"title":["Normal long\u2010term health\u2010related quality of life can be achieved in patients with functional pituitary adenomas having surgery as primary treatment"],"prefix":"10.1111","volume":"82","author":[{"given":"Elina","family":"Ritvonen","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Medicine Helsinki University Central Hospital and University of Helsinki Helsinki 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