{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:12:31Z","timestamp":1775059951783,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"crossref","award":["TRF11643"],"award-info":[{"award-number":["TRF11643"]}],"id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glucocorticoid replacement therapy in patients with adrenal insufficiency needs to be tailored to the individual patient based on body composition and clinical signs and symptoms as no objective method for assessment of treatment adequacy is available. Current treatment regimens are often not satisfactory, which is shown by the adverse metabolic profile and doubled mortality rates in treated adrenal insufficiency patients. Measurement of cortisol concentrations in hair reflect the long\u2010term systemic cortisol exposure and may be of use in refinement of hydrocortisone treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to study whether long\u2010term cortisol (hydrocortisone) levels, as measured in scalp hair, are similar in children with adrenal insufficiency and healthy children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We set up a case control study, measuring anthropometric characteristics and hair cortisol concentrations (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) in 54 hydrocortisone substituted children with adrenal insufficiency (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patients) in the age of 4\u201318\u00a0years and 54 healthy children matched for gender and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> were significantly higher in <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patients compared with healthy controls (mean 13\u00b73 <jats:italic>vs<\/jats:italic> 8\u00b72\u00a0pg\/mg, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b702). <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patients also had a higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) and waist circumference (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b702). <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> was significantly associated with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7002) and <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7002). <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> explained 13% of the difference in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and 29% of the difference in <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> between <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hydrocortisone\u2010treated <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> patients have increased <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> and adverse anthropometric characteristics compared with healthy controls. <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> measurement may be of value in identifying overtreatment and thereby improve hydrocortisone replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12551","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T16:13:15Z","timestamp":1405008795000},"page":"820-825","source":"Crossref","is-referenced-by-count":29,"title":["Elevated hair cortisol concentrations in children with adrenal insufficiency on hydrocortisone replacement therapy"],"prefix":"10.1111","volume":"81","author":[{"given":"G.","family":"Noppe","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Paediatrics Sophia Children's Hospital Erasmus MC Rotterdam The Netherlands"},{"name":"Division of Endocrinology Department of Internal Medicine Erasmus MC Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.F.C.","family":"van 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