{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:09:39Z","timestamp":1785863379416,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health & Medical Research Council (NHMRC)","award":["606553"],"award-info":[{"award-number":["606553"]}]},{"name":"Australian Government's Collaborative Research Networks (CRN)"},{"name":"South Australian Cardiovascular Research Development Program Fellowship","award":["AC11S374"],"award-info":[{"award-number":["AC11S374"]}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"crossref"}]},{"name":"South Australian Department of Health"},{"DOI":"10.13039\/100009843","name":"South Australian Health and Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009843","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) is a complex endocrine disorder associated with insulin resistance, hyperandrogenism, obesity, altered gonadotrophin release and anovulatory infertility. Anti\u2010M\u00fcllerian hormone (<jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>) has been proposed as a marker of ovarian function and fertility. Across a cohort of lean and overweight women with and without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, we investigated the association of <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> with insulin resistance and body composition using gold standard measures. A secondary aim was to examine whether <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> was useful to determine <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 22 lean and 21 overweight women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 19 lean and 16 overweight non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> healthy controls were recruited. <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> was diagnosed based on the Rotterdam criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Euglycaemic\u2010hyperinsulinaemic clamp for assessing insulin resistance, dual energy X\u2010ray absorptiometry and computed tomography for assessing adiposity, and blood sampling for the assessment of androgens, gonadotrophins and <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010M\u00fcllerian hormone levels were increased in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;0\u00b7001) regardless of adiposity, with this increase associated with testosterone (<jats:italic>P<\/jats:italic>\u00a0&lt;0\u00b7001) rather than insulin resistance (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b779), adiposity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b798) or gonadotrophins. In assessing the ability of <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> to predict <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, a value of 30\u00a0pmol\/l or higher indicated 79% of women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were correctly identified as having the condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010M\u00fcllerian hormone appears primarily related to androgen status suggesting a direct and predominant role of androgens in the pathophysiology of reproductive dysfunction in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. As <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content> reflects <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> status, it may also be useful in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12557","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T12:35:00Z","timestamp":1405600500000},"page":"899-906","source":"Crossref","is-referenced-by-count":61,"title":["Polycystic ovary syndrome and anti\u2010M\u00fcllerian hormone: role of insulin resistance, androgens, obesity and gonadotrophins"],"prefix":"10.1111","volume":"81","author":[{"given":"Samantha","family":"Cassar","sequence":"first","affiliation":[{"name":"College of Sport and Exercise Science Victoria University Melbourne Vic. Australia"},{"name":"Institute of Sport, Exercise and Active Living Victoria University Melbourne Vic. Australia"},{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J.","family":"Teede","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"},{"name":"Diabetes and Vascular Medicine Unit Monash Health Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Moran","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"},{"name":"The Robinson Research Institute Discipline of Obstetrics and Gynaecology University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju E.","family":"Joham","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryce L.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyd J.","family":"Strauss","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel K.","family":"Stepto","sequence":"additional","affiliation":[{"name":"College of Sport and Exercise Science Victoria University Melbourne Vic. Australia"},{"name":"Institute of Sport, Exercise and Active Living Victoria University Melbourne Vic. Australia"},{"name":"Monash Centre for Health Research and Implementation School of Public Health and Preventive Medicine Monash University Melbourne Vic. 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