{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:42:52Z","timestamp":1788212572092,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF) of Korea","doi-asserted-by":"crossref","award":["NRF-2012R1A1A2038383"],"award-info":[{"award-number":["NRF-2012R1A1A2038383"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Serum calcitonin (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) level is used to detect medullary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>), but the cut\u2010off level is unclear. We aimed at identifying the optimal cut\u2010off value of basal serum <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> levels for detecting <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>We retrospectively enrolled patients with hypercalcitoninemia (\u22652\u00b79\u00a0pmol\/l) who had undergone thyroid ultrasonography (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>) and subsequent work\u2010up between 2001 and 2013 at <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>san <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enter. We divided patients into four groups: proven <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> (group 1, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>93), pathologically proven non\u2010<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> after surgery (group 2, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>57), benign single nodule by cytology (group 3, <jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>68) and patients without nodules on <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> (group 4, <jats:italic>n\u00a0=\u00a0<\/jats:italic>24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement<\/jats:title><jats:p>Basal serum <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> levels were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> level of group 1 (119\u00b75\u00a0pmol\/l) was significantly higher than those of other groups (4\u00b70, 3\u00b78 and 3\u00b78\u00a0pmol\/l, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). When we adopted 19\u00b70\u00a0pmol\/l of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> level as a cut\u2010off value, the sensitivity, specificity, and positive and negative predictive values were 77\u00b74%, 98\u00b77%, 97\u00b73% and 87\u00b78%, respectively. When we compared 29\u00b72\u00a0pmol\/l (100\u00a0pg\/ml) and 19\u00b70\u00a0pmol\/l (65\u00a0pg\/ml) as cut\u2010off values, 19\u00b70\u00a0pmol\/l was more sensitive and accurate than 29\u00b72\u00a0pmol\/l. Factors associated with hypercalcitoninemia in non\u2010<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> groups were autoimmune thyroiditis, chronic kidney disease, proton pump inhibitors and other malignancies. Serum <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> levels tended to decrease spontaneously in non\u2010<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Basal serum <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> levels higher than 19\u00b70\u00a0pmol\/l can be a useful cut\u2010off value for detecting macroscopic <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>, even though values below 19\u00b70\u00a0pmol\/l cannot exclude the presence of <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> like small volume <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> or premalignant <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010cell hyperplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12562","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T07:08:06Z","timestamp":1405753686000},"page":"598-603","source":"Crossref","is-referenced-by-count":21,"title":["A cut\u2010off value of basal serum calcitonin for detecting macroscopic medullary thyroid carcinoma"],"prefix":"10.1111","volume":"82","author":[{"given":"Hyemi","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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