{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:44:02Z","timestamp":1790772242807,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,14]],"date-time":"2014-08-14T00:00:00Z","timestamp":1407974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The early detection of medullary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>) can improve patient prognosis, because histological stage and patient age at diagnosis are highly relevant prognostic factors. As a consequence, delay in the diagnosis and\/or incomplete surgical treatment should correlate with a poorer prognosis for patients. Few papers have evaluated the specific capability of fine\u2010needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) to detect <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>, and small series have been reported. This study conducts a meta\u2010analysis of published data on the diagnostic performance of <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> to provide more robust estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research Design and Methods<\/jats:title><jats:p>A comprehensive computer literature search of the PubMed\/<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Embase and Scopus databases was conducted by searching for the terms \u2018medullary thyroid\u2019 <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> \u2018cytology\u2019, \u2018<jats:styled-content style=\"fixed-case\">FNA<\/jats:styled-content>\u2019, \u2018<jats:styled-content style=\"fixed-case\">FNAB<\/jats:styled-content>\u2019, \u2018<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>\u2019, \u2018fine needle\u2019 or \u2018fine\u2010needle\u2019. The search was updated until 21 March 2014, and no language restrictions were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen relevant studies and 641 <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> lesions that had undergone <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> were included. The detection rate (<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>) of <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> (diagnosed as \u2018<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>\u2019 or \u2018suspicious for <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>\u2019) on a per lesion\u2010based analysis ranged from 12\u00b75% to 88\u00b72%, with a pooled estimate of 56\u00b74% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 52\u00b76\u201360\u00b71%). The included studies were statistically heterogeneous in their estimates of <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> (I\u2010square &gt;50%). Egger's regression intercept for <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> pooling was 0\u00b703 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22123\u00b71 to 3\u00b72, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b79). The study that reported the largest <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> series had a <jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content> of 45%. Data on immunohistochemistry for calcitonin in diagnosing <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> were inconsistent for the meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented meta\u2010analysis demonstrates that <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> is able to detect approximately one\u2010half of <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> lesions. These findings suggest that other techniques may be needed in combination with <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> to diagnose <jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content> and avoid false negative results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12563","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T16:25:10Z","timestamp":1405959910000},"page":"280-285","source":"Crossref","is-referenced-by-count":175,"title":["Detection rate of <scp>FNA<\/scp> cytology in medullary thyroid carcinoma: a meta\u2010analysis"],"prefix":"10.1111","volume":"82","author":[{"given":"Pierpaolo","family":"Trimboli","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Diabetology Ospedale Israelitico Rome Italy"},{"name":"Department of Nuclear Medicine and Thyroid Centre Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Thyroid Centre Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Guidobaldi","sequence":"additional","affiliation":[{"name":"Section of Pathology Ospedale Israelitico Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Nigri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Ospedale S. Andrea Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Valabrega","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Ospedale S. Andrea Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Section of Pathology University Hospital Campus Bio Medico Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Faquin","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Giovanella","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Thyroid Centre Oncology Institute of Southern Switzerland Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1139::AID-CNCR26>3.0.CO;2-Z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.03.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.05.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.16.3.468"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23449"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ12-0050"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0062-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030550"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20269"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326191"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.1267"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0326"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0338"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21566"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00747.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP12420.OR"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13143.OR"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22976"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12234"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2013.12.004"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0019-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21802"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291344"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21731"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2033"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200006)22:6<351::AID-DC5>3.0.CO;2-T"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981025)84:5<295::AID-CNCR5>3.0.CO;2-J"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010014\u20100226\u2010x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12563","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:23:06Z","timestamp":1695565386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,14]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/cen.12563"],"URL":"https:\/\/doi.org\/10.1111\/cen.12563","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,14]]}}}