{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:11:51Z","timestamp":1785773511057,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP111103"],"award-info":[{"award-number":["MOP111103"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> is an essential regulator of mineral metabolism; <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> hypersecretion may result in hyperparathyroidism including normocalcaemic, primary and secondary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the characteristics of participants with hyperparathyroid states and the relationship to bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and participants<\/jats:title><jats:p>A cross\u2010sectional study of 1872 community\u2010dwelling men and women aged 35+ years (mostly Caucasian) with available serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> from Year 10 Canadian Multicentre Osteoporosis Study follow\u2010up (2005\u201307). <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was determined using a second\u2010generation chemiluminescence immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>L1\u2010L4, femoral neck and total hip <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We established a <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> reference range (2\u00b77\u201310\u00b72\u00a0pmol\/l) based on healthy participants (i.e. normal serum calcium, serum 25\u2010hydroxyvitamin D, kidney function and body mass index, who were nonusers of antiresorptives, glucocorticoids and diuretics and not diagnosed with diabetes or thyroid disease). Participants with <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels in the upper reference range (5\u00b76\u201310\u00b72\u00a0pmol\/l), representing a prevalence of 10\u00b77%, had lower femoral neck and total hip <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, by 0\u00b7030\u00a0g\/cm<jats:sup>2<\/jats:sup> [95% confidence interval: 0\u00b7009; 0\u00b7051] and 0\u00b7025\u00a0g\/cm<jats:sup>2<\/jats:sup> (0\u00b7001; 0\u00b7049), respectively, than those with levels 2\u00b77\u20135\u00b76\u00a0pmol\/l. Participants with normocalcaemic and secondary hyperparathyroidism also had lower total hip <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> than those with levels 2\u00b77\u20135\u00b76\u00a0pmol\/l, and CaMos prevalences of normocalcaemic, primary and secondary hyperparathyroidism were 3\u00b73%, 1\u00b74% and 5\u00b72%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found reduced <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in participants with accepted hyperparathyroid states but also a notable proportion of other participants that might benefit from having lower <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12569","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T11:06:52Z","timestamp":1406286412000},"page":"359-368","source":"Crossref","is-referenced-by-count":36,"title":["Characteristics of hyperparathyroid states in the Canadian multicentre osteoporosis study (CaMos) and relationship to skeletal markers"],"prefix":"10.1111","volume":"82","author":[{"given":"C.","family":"Berger","sequence":"first","affiliation":[{"name":"CaMos Coordinating Centre McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Almohareb","sequence":"additional","affiliation":[{"name":"Specialized Diabetes and Endocrine Center King Fahad Medical City Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Langsetmo","sequence":"additional","affiliation":[{"name":"CaMos Coordinating Centre McGill University Montreal QC 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