{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:28:46Z","timestamp":1774801726037,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T00:00:00Z","timestamp":1412294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170569"],"award-info":[{"award-number":["81170569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Polymorphisms in the follicle\u2010stimulating hormone receptor (<jats:styled-content style=\"fixed-case\">FSHR<\/jats:styled-content>) gene are reported to be associated with the ovarian response in controlled ovarian hyperstimulation (<jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>), although there remains some discordance between studies. Here, using the largest patient sample to date, we evaluated the association of the p.Ser680Asn (S<jats:sup>680<\/jats:sup>N) polymorphism in the <jats:styled-content style=\"fixed-case\">FSHR<\/jats:styled-content> gene with the outcome of <jats:styled-content style=\"fixed-case\">COH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Medical academy and hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 1250 infertile Chinese women undergoing <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICIS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> treatment were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measures<\/jats:title><jats:p>The association between an <jats:italic>FSHR<\/jats:italic> polymorphism (S<jats:sup>680<\/jats:sup>N) and the ovarian response was analysed. Genotyping was performed by utilizing direct sequencing and the Sequenom MassARRAY <jats:styled-content style=\"fixed-case\">iPLEX<\/jats:styled-content> platform. Follicular fluid oestradiol (E<jats:sub>2<\/jats:sub>) and follicle\u2010stimulating hormone (FSH) concentrations were determined using electrochemiluminesence immunoassays. The ovarian response parameters were analysed based on the <jats:italic>FSHR<\/jats:italic> genotypes. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for the risk genotypes and alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were linear correlations between the basal <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> level, exogenous gonadotropin consumption, and oocytes retrieved and the Ser680 alleles. Patients in the homozygous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> group demonstrated higher basal <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> levels, required more dosage of exogenous gonadotropin for ovarian stimulation, and had fewer numbers of oocytes retrieved compared with patients in the homozygous <jats:styled-content style=\"fixed-case\">NN<\/jats:styled-content> and heterozygous groups. Logistic regression analysis revealed that the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> of a poor ovarian response for the <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content> genotype was 1\u00b779 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b728\u20132\u00b761; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), whereas that for the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> genotype was 2\u00b725 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b740\u20133\u00b758; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) after adjusting for age, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and basal <jats:styled-content style=\"fixed-case\">FSH<\/jats:styled-content> level. The concentration of E<jats:sub>2<\/jats:sub> in the follicular fluid was significantly higher in subjects with the <jats:styled-content style=\"fixed-case\">NN<\/jats:styled-content> genotype than the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content> genotype (772\u00a0\u00b1\u00a0545\u00a0ng\/ml vs. 1299\u00a0\u00b1\u00a0504\u00a0ng\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follicle\u2010stimulating hormone receptor gene polymorphism at position 680 is associated with different ovarian responses to controlled ovarian hyperstimulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12573","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T09:22:18Z","timestamp":1406798538000},"page":"577-583","source":"Crossref","is-referenced-by-count":43,"title":["The Ser680Asn polymorphism in the follicle\u2010stimulating hormone receptor gene is associated with the ovarian response in controlled ovarian hyperstimulation"],"prefix":"10.1111","volume":"82","author":[{"given":"Xianliang","family":"Huang","sequence":"first","affiliation":[{"name":"Fudan University Shanghai China"},{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Ji Ai Genetics &amp; IVF Institute Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Hong","sequence":"additional","affiliation":[{"name":"Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijin","family":"Zhou","sequence":"additional","affiliation":[{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Shi","sequence":"additional","affiliation":[{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Ji Ai Genetics &amp; IVF Institute Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Obstetrics and Gynecology Hospital of Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[{"name":"NPFPC Laboratory of Contraception and Devices Shanghai Institute of Planned Parenthood Research Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90151-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.6.6.629"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml034"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(11)60012-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02893-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1434.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-008-9041-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-011-9192-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0624"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3365"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/8.10.893"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.04.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.08.037"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.12.040"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.012"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.11.093"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2010.03.018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0212s60"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290272"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1304"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.09.110"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112799361954"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2010.12.006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei317"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fpc.0000167330.92786.5e"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.156"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112799362007"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.04.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.2.751"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1492-x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200405000-00003"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12573","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:56:30Z","timestamp":1695545790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,3]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/cen.12573"],"URL":"https:\/\/doi.org\/10.1111\/cen.12573","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,3]]}}}