{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:16:21Z","timestamp":1778807781270,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81301790"],"award-info":[{"award-number":["81301790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Prophylactic central lymph node dissection (CLND<\/jats:styled-content>) in clinically node\u2010negative patients remains controversial, and predictive factors for central lymph node metastasis (CLNM<\/jats:styled-content>) in patients with papillary thyroid carcinoma (PTC<\/jats:styled-content>) are not well defined. Herein, we conducted a systematic review to quantify the clinicopathologic factors predictive for CLNM<\/jats:styled-content> in patients with PTC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A systematic search of electronic databases (PubMed, Embase, Cochrane CENTRAL<\/jats:styled-content>, Scopus and Wanfang Database) for studies published until July 2014 was performed. Cohort, case\u2013control studies and randomized controlled trials that examined clinical risk factors of CLNM<\/jats:styled-content> were included.<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010five studies (4 prospective and 21 retrospective studies) involving 7,719 patients met final inclusion criteria. From the pooled analyses, male gender (OR<\/jats:styled-content> 1\u00b793, 95% CI<\/jats:styled-content> 1\u00b740 to 2\u00b764), tumour multifocality (OR<\/jats:styled-content> 1\u00b793, 95% CI<\/jats:styled-content> 1\u00b762 to 2\u00b730), tumour size >0\u00b75\u00a0cm (OR<\/jats:styled-content> 3\u00b748, 95% CI<\/jats:styled-content> 2\u00b724 to 5\u00b741), capsular invasion (OR<\/jats:styled-content> 1\u00b791, 95% CI<\/jats:styled-content> 1\u00b736 to 2\u00b767), extrathyroidal extension (OR<\/jats:styled-content> 2\u00b742, 95% CI<\/jats:styled-content> 1\u00b758 to 3\u00b771), lymphovascular invasion (OR<\/jats:styled-content> 13\u00b729, 95% CI<\/jats:styled-content> 5\u00b761 to 31\u00b748) and lateral lymph node metastasis (OR<\/jats:styled-content> 14\u00b733, 95% CI<\/jats:styled-content> 5\u00b734 to 38\u00b750) were significantly associated with increased risk of CLNM<\/jats:styled-content>, while age >45\u00a0years (OR<\/jats:styled-content> 0\u00b765, 95% CI<\/jats:styled-content> 0\u00b751 to 0\u00b783) and lymphocytic thyroiditis (OR<\/jats:styled-content> 0\u00b770, 95% CI<\/jats:styled-content> 0\u00b753 to 0\u00b792) resulted in decreased risk of CLNM<\/jats:styled-content>. Bilaterality and tumour location were not significantly associated with CLNM<\/jats:styled-content> development (all P<\/jats:italic>\u00a0>\u00a00\u00b705).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our analysis identified several clinicopathologic factors associated with CLNM<\/jats:styled-content>. These findings may guide the necessity and extent of prophylactic CLND<\/jats:styled-content> and ultimately improve the outcomes of patients with PTC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12583","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T10:08:32Z","timestamp":1408702112000},"page":"124-132","source":"Crossref","is-referenced-by-count":75,"title":["Clinical risk factors for central lymph node metastasis in papillary thyroid carcinoma: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"83","author":[{"given":"Hui","family":"Qu","sequence":"first","affiliation":[{"name":"Department of General Surgery Shandong University Qilu Hospital Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010rui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shandong University Qilu Hospital Shandong 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