{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:42:18Z","timestamp":1780569738684,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Post\u2010partum thyroiditis (<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>) is a common phenomenon in the general population. To date there have been few studies examining the incidence of <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> in women with hypothyroidism antedating pregnancy. This study aimed to assess the incidence and potential predictors of <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> in women with treated hypothyroidism antedating pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We compiled a cohort of 97 women with previous hypothyroidism antedating pregnancy seen in the Endocrinology in Pregnancy clinic from 1999 to 2011, collecting data on thyroid function, antibodies and levothyroxine doses post\u2010partum. The incidence of <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> and its predictors were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 (68%) women had fluctuations in thyroid function consistent with <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>. Of these, 22 (33%) had a hyperthyroid phase alone, 22 (33%) had a hypothyroid phase alone and 22 (33%) had both a hyper and hypo phase. The majority of women had their dose of thyroid medication adjusted during the <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> episode. Women who were on a full dose of thyroxine post\u2010partum were significantly less likely to have a hypothyroid phase. In multivariable analysis, the only predictor of <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> was the presence of thyroid antibodies, with 83% of antibody positive women having <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> compared to 44% of antibody negative women (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our cohort, 2\/3 of women had fluctuations in thyroid function consistent with <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> and most required adjustment of their thyroid dose. Women with hypothyroidism antedating pregnancy are at high risk for <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> and should be closely monitored during the first year post\u2010partum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12604","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T19:51:56Z","timestamp":1409860316000},"page":"389-393","source":"Crossref","is-referenced-by-count":16,"title":["Changes suggestive of post\u2010partum thyroiditis in women with established hypothyroidism: incidence and predictors"],"prefix":"10.1111","volume":"83","author":[{"given":"Melissa","family":"Sergi","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Dalla Lana School of Public Health University of Toronto Toronto ON Canada"},{"name":"Department of Medicine University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denice S.","family":"Feig","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Toronto ON Canada"},{"name":"Division of Endocrinology and Metabolism Mount Sinai Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(95)80883-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1001\/archinte.1990.00390190063008","article-title":"How common is postpartum thyroiditis? 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