{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:42Z","timestamp":1787014002027,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To study the interaction between copeptin and hypothalamic\u2013pituitary\u2013adrenal (\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      ) activation in men and women during hypoglycaemic stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and patients<\/jats:title>\n                    <jats:p>\n                      A prospective study in 118 patients (mean age 47\u00b77\u00a0\u00b1\u00a013\u00b76\u00a0years,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a052 women) undergoing insulin tolerance testing for suspected pituitary dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Serum copeptin was measured in serially collected blood samples and assessed in relation to\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      , cortisol and other endocrine parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Symptomatic hypoglycaemia (mean glucose nadir, 1\u00b76\u00a0\u00b1\u00a00\u00b75\u00a0mmol\/l) resulted in a rapid significant increase of serum copeptin. Individuals with impaired pituitary function had lower stress\u2010induced copeptin levels (median, 6\u00b726\u00a0pmol\/l) than patients with intact pituitary (8\u00b746\u00a0pmol\/l,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00b7001). A weak overall correlation between stress\u2010induced copeptin and cortisol levels was observed (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00\u00b731,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00b7001). In female individuals, there was a positive correlation between stress\u2010induced copeptin and\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00\u00b747,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00b7001) or cortisol levels (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00\u00b742,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b7002), while in males, no correlation with\n                      <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\n                      levels (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00\u00b703,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b775) and poor correlation with cortisol levels (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>s<\/jats:sub>\n                      \u00a0=\u00a00\u00b724,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b7045) was observed. Patients with central diabetes insipidus showed lowest baseline (2\u00b720\u00a0pmol\/l) and stimulated copeptin levels (3\u00b768\u00a0pmol\/l).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The data from this study indicate that stress\u2010induced release of\n                      <jats:styled-content style=\"fixed-case\">AVP<\/jats:styled-content>\n                      in women, but not in men, is linked to the co\u2010activation of the hypothalamic\u2013pituitary\u2013adrenal system.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.12608","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T12:50:53Z","timestamp":1410180653000},"page":"570-576","source":"Crossref","is-referenced-by-count":28,"title":["Gender\u2010specific co\u2010activation of arginine vasopressin and the hypothalamic\u2013pituitary\u2013adrenal axis during stress"],"prefix":"10.1111","volume":"82","author":[{"given":"S.","family":"Kacheva","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes University Hospital RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kolk","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes University Hospital RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.","family":"Morgenthaler","sequence":"additional","affiliation":[{"name":"Experimental Endocrinology Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Brabant","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Endocrinology Med. Clinic I University of Luebeck Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Karges","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes University Hospital RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2006.09.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.67.040403.120816"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2046"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00403-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2011-1202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2337"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/299355a0"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/305325a0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1985.tb02998.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2004.09.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01613.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00196-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-122-2-444"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000125702"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(82)90411-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70207-3"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.060038"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.11.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1426"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2345"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0232"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2350"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90181-3"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401150"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0982"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0179"},{"key":"e_1_2_6_28_1","first-page":"341","article-title":"Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level","volume":"29","author":"Katan M.","year":"2008","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.4.1893"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.12.058"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.03.022"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3451"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0130313"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00469.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1210\/endo.139.7.6121","article-title":"Glucocorticoids increase vasopressin V1b receptor coupling to phospholipase C","volume":"139","author":"Rabadan\u2010Diehl C.","year":"1998","journal-title":"Endocrinology"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12608","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:56:54Z","timestamp":1695531414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/cen.12608"],"URL":"https:\/\/doi.org\/10.1111\/cen.12608","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}